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Research Journal of Medicinal Plants
  Year: 2020 | Volume: 14 | Issue: 2 | Page No.: 72-78
DOI: 10.3923/rjmp.2020.72.78
 
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Therapeutic Potential of Methanolic Extract of Fruits of Physalis angulata against Salmonella typhi Infection

Tolulope O. Oladosu, Tinuola T. Adebolu and Muftau K. Oladunmoye

Abstract:
Background and Objective: Drug resistant Salmonella typhi is an alarming issue in the health sector which has drawn attention of researchers to search for alternative therapeutic sources. Due to increase in resistance of Salmonella typhi to antibiotics, the efficacy of methanolic extract of fruits of Physalis angulata (PFM) in treating S. typhi infection was investigated in present study. Materials and Methods: Apparently healthy Wistar rats were orogastrically challenged with ID of S. typhi multi-antibiotic resistant (MAR) isolate. At onset of signs of illness, the infected rats were divided into three groups-the first group was treated with the minimum inhibitory concentration (MIC) of the extract (400 mg kg1 b.wt.) the second group with minimum bactericidal concentration (MBC ) of the extract (500 mg kg1 b.wt.) while the third group was left untreated. Haematological and histopathological studies were carried out on the blood and the vital internal organs of the rats respectively at the termination of treatment. Liver function tests were also carried out on the rats. Results: Treatment of S. typhi infected rats with PFM (400, 500 mg kg1 b.wt.) caused the recovery of the rats between 2 and 3 days and also caused the packed cell volume (PCV) of the infected rats to increase from 30.00±0.10% to 39.00±0.50% and 41.00± 0.20%, respectively. A similar trend was observed for haemoglobin, Red Blood Cells (RBCs) and neutrophil counts. On the other hand, it caused the counts of total White Blood Cells (WBC) and lymphocyte of the S. typhi infected rats which shot up as a result of the infection to reduce considerably. Conclusion: Hence, concluded that PFM exerted therapeutic, haematinic and immunomodulatory effects on the S. typhi infected rats treated with the extract.
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How to cite this article:

Tolulope O. Oladosu, Tinuola T. Adebolu and Muftau K. Oladunmoye, 2020. Therapeutic Potential of Methanolic Extract of Fruits of Physalis angulata against Salmonella typhi Infection. Research Journal of Medicinal Plants, 14: 72-78.

DOI: 10.3923/rjmp.2020.72.78

URL: https://scialert.net/abstract/?doi=rjmp.2020.72.78

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