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Research Journal of Medicinal Plants
  Year: 2020 | Volume: 14 | Issue: 4 | Page No.: 167-173
DOI: 10.3923/rjmp.2020.167.173
 
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Hepatoprotective and Nephroprotective Potency of Ricinodendron heudelotii Against Acetaminophen-induced Toxicity in Wistar Albino Rats

T. Odinga and Essien Eka

Abstract:
Background and Objective: The seeds of the plant Ricinodendron heudelotii are used in preparation of various meals and eaten for its delicious taste and aroma. Its extract has been used in many Nigerian communities in the treatment of various health disorders. This study evaluated the activity of ethanol seed extracts of Ricinodendron heudelotii on acetaminophen-induced hepatic/nephrotoxicity in male Wistar albino rats. Materials and Methods: Thirty rats were divided into six groups of six rats each. Five of these groups were induced with acetaminophen. Three of the groups were thereafter treated with different concentrations of the ethanol seed extracts of Ricinodendron heudelotii. Treatment was carried out for a period of 21 days, the animals were sacrificed and blood samples were collected for biochemical analysis and histological examinations of the hepatic and renal cells. Results: The results obtained revealed an amelioration of the acetaminophen-induced toxicity in the hepatic cells of the experimental animals as seen in the concentrations of total protein, total and conjugated bilirubin, albumin, AST and ALP. The renal function biomarkers tested showed a decrease in the elevated blood urea nitrogen, creatinine levels and the blood electrolytes at all concentrations except 800 mg kg1 b.wt. of extract concentration. The histological examination of the cells also revealed amelioration of the integrity of the cells when treated with the seed extract. Conclusion: The results obtained from the study, therefore, suggested that Ricinodendron heudelotii ethanol seed extract has an ameliorative/protective potency against acetaminophen-induced toxicity on the hepatic and renal cells.
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How to cite this article:

T. Odinga and Essien Eka, 2020. Hepatoprotective and Nephroprotective Potency of Ricinodendron heudelotii Against Acetaminophen-induced Toxicity in Wistar Albino Rats. Research Journal of Medicinal Plants, 14: 167-173.

DOI: 10.3923/rjmp.2020.167.173

URL: https://scialert.net/abstract/?doi=rjmp.2020.167.173

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