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Research Journal of Medicinal Plants
  Year: 2020 | Volume: 14 | Issue: 3 | Page No.: 133-143
DOI: 10.3923/rjmp.2020.133.143
 
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In-silico Evaluation of Wound Healing Potential of Euphorbia tithymaloides

Rahul S. Adnaik , Vyankatesh R. Dharanguttikar, Swapnali A. Thorat, Pratibha R. Adnaik, Prajakta D. Nayakal and Sanket S. Patil

Abstract:
Background and Objective: The wound healing after the injury is a complex process by which the skin and the tissue under the skin fix themselves. Euphorbia Tithymaloides has various therapeutic uses, such as antiprotozoa, anti-inflammatory, antiplasmodial, antimicrobial and so on. The goal of this study was to predict wound healing medicinal products with a focus on the in silico effect of chemical constituents on wound healing process. Materials and Methods: In silico molecular docking of reducing sugar present in Euphorbia tithymaloides was performed using two receptors of leukotriene such as structural basis of the proinflammatory signaling complex mediated by TSLP PDB ID: 4NN5, Crystal structure of the type-I interleukin-1 receptor complexes with interleukin-1beta PDB ID: 1ITB and second two receptor of NF-κB which are Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements PDB ID: 5E69 and Structure–function analyses of the bacterial zinc metalloprotease effectors protein GtgA+ uncover key residues required for deactivating NF-B PDB ID:6GGR. Results: As a result, D-Ribose has a dock score of-51.51and -75.56 Kcal mol1 against TSLP and interleukin-1 receptor type-I in the first test. And second result D-Ribose dock score of -76.42 and -64.69 Kcal mol1 against two NF-ÿB receptors that predicted interaction with selected protein structure via strong hydrogen bonding, with good docking score ensuring significant binding affinity with selected protein structure. Conclusion: The current research offers a significant approach to the reducing sugar derivative's structural requirements that would make it possible for the wound healing mechanism to interact with the receptors concerned.
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How to cite this article:

Rahul S. Adnaik, Vyankatesh R. Dharanguttikar, Swapnali A. Thorat, Pratibha R. Adnaik, Prajakta D. Nayakal and Sanket S. Patil, 2020. In-silico Evaluation of Wound Healing Potential of Euphorbia tithymaloides. Research Journal of Medicinal Plants, 14: 133-143.

DOI: 10.3923/rjmp.2020.133.143

URL: https://scialert.net/abstract/?doi=rjmp.2020.133.143

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