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Research Journal of Medicinal Plants
  Year: 2020 | Volume: 14 | Issue: 3 | Page No.: 119-124
DOI: 10.3923/rjmp.2020.119.124
 
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Combination of Andrographis panniculata Ness, Curcuma xanthoriza Roxb and Cinnamommum burmanii as Appetite Enhancer with Low Infertility Risk

Septin Putri Abriyanti, Wahyu Dewi Tamayanti , Lisa Soegianto, Iwan Sahrial Hamid and Ratna Megawati Widharna

Abstract:
Background and Objectives: The main ingredients of Sambiloto (Andrographis panniculata Ness), Temulawak (Curcuma xanthoriza Roxb) and Kayu Manis (Cinnamomum burmanii) are andrografolid, curcumin and cinnamaldehyde, respectively. These compounds, in individual usage were reported as appetite enhancer in Wistar rats, but they caused infertility in male rats. This study therefore aimed to test the effectivity improvement of these compounds as appetite and fertility enhancer when administered as combination. Materials and Methods: A total of 36 male Wistar rats were divided into several groups including: treatment groups that were administered: Sambiloto-Temulawak-Kayu manis (STK), Sambiloto-Temulawak (ST), Sambiloto-Kayu manis (SK), Temulawak-Kayu manis (TK), a positive control group was Tracetate treated and a group that was treated with vehicle. At the end of 28 days treatment, rats were sacrificed, testicle and spermatozoa were collected. The impairment of testicle tubules and reduction of primary spermatocyte amount were observed. Results: The body weights of rats were increased in all the treatment groups as compared to negative control group. Similar trend was observed in the percentage of food intake. Wistar rats in Sambiloto-Temulawak-Kayu manis (STK) group showed the lowest number of both spermatozoa viability of 41.33±4.01% (0.0004) and primary spermatocyte count of 43.70±6.91 cells (0.0044), but no impairment in seminiferous tubules was observed. Conclusion: The combination of sambiloto, temulawak and kayu manis (60:140:50 mg kg1 b.wt.) increased body weight and food intake of male rats in this study. Sambiloto-Temulawak (ST) group shown as the best combination to increase body weight of rats with the lowest infertility effect.
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How to cite this article:

Septin Putri Abriyanti, Wahyu Dewi Tamayanti, Lisa Soegianto, Iwan Sahrial Hamid and Ratna Megawati Widharna, 2020. Combination of Andrographis panniculata Ness, Curcuma xanthoriza Roxb and Cinnamommum burmanii as Appetite Enhancer with Low Infertility Risk. Research Journal of Medicinal Plants, 14: 119-124.

DOI: 10.3923/rjmp.2020.119.124

URL: https://scialert.net/abstract/?doi=rjmp.2020.119.124

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