Submit Manuscript

Research Journal of Medicinal Plants

Year: 2015 | Volume: 9 | Issue: 2 | Page No.: 60-71
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 551

Search

Authors

Abiodun Humphrey Adebayo

Oyinlade Cecilia Ogundare

Oluwatobi Samuel Adegbite

Keywords

The study was aimed at investigating the sub-acute evaluation of the extract of Syzygium malaccense in albino rats. Five groups of eight rats per group were orally administered with graded 50, 100, 250 and 500 mg kg-1 b.wt. doses of the extract for 28 days. Blood samples of the sacrificed rats were collected for biochemical and haematological studies while liver and kidney tissues were used for histopathological assessment. The results showed an LD50 of 1224.75 mg kg-1 b.wt. with no significant (p>0.05) changes in weight of organs tested. Biochemical parameters such as AST, ALP, protein and albumin levels in all the treated animals did not change significantly, however, there was significant (p<0.05) change in the activity of ALT as well as haematological parameters such as RBC, WBC, HGB, platelet counts, MCV and MCH when compared with the control group. The results from histopathology showed an inflammation of the liver cells at doses beyond 100 mg kg-1 b.wt. but there was no significant damage to the kidney tissue. It may be concluded that the extract of S. malaccense possesses the tendency of affecting the haematopoietic elements and may also alter the structural integrity of the liver tissue if ingested at higher doses.
PDF Fulltext XML References Citation

How to cite this article

Abiodun Humphrey Adebayo, Oyinlade Cecilia Ogundare and Oluwatobi Samuel Adegbite, 2015. Sub-Acute Evaluation of Extract of Syzygium malaccense in Albino Rats. Research Journal of Medicinal Plants, 9: 60-71.

URL: https://scialert.net/abstract/?doi=rjmp.2015.60.71

Related Articles

Nutritional Qualities of Three Medicinal Plant Parts (Xylopia aethiopica, Blighia sapida and Parinari polyandra) commonly used by Pregnant Women in the Western Part ofNigeria
The Effects of Ethanolic Leaf Extract of Commiphora africana (Buseraceae) on Lipid Profile in Rats
The Effects of Ethanolic Leaf Extract of Commiphora africana (Burseraceae) on Rat Liver and Kidney Functions
Acute and Sub-chronic Toxicity Studies of Crude Aqueous Extract of Albizzia chevalieri Harms (Leguminosae)

Leave a Comment

Your email address will not be published. Required fields are marked *