Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2015 | Volume: 9 | Issue: 8 | Page No.: 406-416
DOI: 10.3923/rjmp.2015.406.416
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Modulatory Effects of Alstonia scholaris on Biochemical and Antioxidant Parameters in Experimentally Induced Hepatotoxicity in Wistar Rats

Pawan Kumar Verma, Rajinder Raina, Mudasir Sultana and Maninder Singh

Abstract:
Alstonia scholaris (Apocynaceae) is an important constituent of numerous ayurvedic preparations. The present study was aimed to evaluate the modulatory effects of Alstonia scholaris on biochemical and antioxidant parameters in acetaminophen (APAP) induced hepatotoxicity. Hepatic biomarkers viz. aspartate and alanine aminotransferases (AST, ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), Gamma Glutamyl Transferase (GGT), paraoxonase (PON1), arylesterase (AE), ceruloplasmin (CP), bilirubin, plasma proteins and oxidative stress biomarkers like Total Oxidant Status (TOS), Total Antioxidant Status (TAS), blood glutathione (GSH), total thiols (TTH), glucose-6-phosphate dehydrogenase (G6PDH), malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and Glutathione-S-Transferase (GST) activities were estimated to assess the extent of hepatic damage induced by APAP and the protection imparted against it by leaf extracts. Oral administration of APAP, hepatotoxicity indicated by increased (p<0.05) activities of AST, ALT, ALP, GGT, G6PDH, total bilirubin and TOS while decreased TAS, CAT, SOD, GPx, GST, TTH, GSH, PON1, AE, TTH, direct bilirubin, total plasma proteins and albumin in plasma was observed. The treatments with either aqueous or ethanolic leaf extract of A. scholaris restored the activities of ALT, GGT, ALP, LDH, PON1, AE, G6PDH, GPx, CAT, GSH, TTH, TAS and MDA in APAP induced hepatotoxicity. Hepatic and oxidative damage biomarkers indicated that treatments with aqueous or ethanolic leaf extract minimized APAP induced hepatic damage. High correlation coefficients between PON1/AE ratio and TTH levels and increased TAS, GSH levels suggests ethanolic extract to have higher hepatoprotective potential compared to aqueous extract of A. scholaris.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Pawan Kumar Verma, Rajinder Raina, Mudasir Sultana and Maninder Singh, 2015. Modulatory Effects of Alstonia scholaris on Biochemical and Antioxidant Parameters in Experimentally Induced Hepatotoxicity in Wistar Rats. Research Journal of Medicinal Plants, 9: 406-416.

DOI: 10.3923/rjmp.2015.406.416

URL: https://scialert.net/abstract/?doi=rjmp.2015.406.416

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

Curve Bottom