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Research Journal of Medicinal Plants
  Year: 2015 | Volume: 9 | Issue: 3 | Page No.: 116-126
DOI: 10.3923/rjmp.2015.116.126
 
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Promotion of Wound Healing by Leaf Extracts of Sesbania aegyptiaca in Albino Rats

Nata Rajan Livingston Raja and Krishnan Sundar

Abstract:
The wound-healing activity of Sesbania aegyptiaca leaf extract ointment was evaluated in albino rats. The animals were divided into 4 groups of five each. In Group 1 control animals ‘simple ointment’ was applied on the wounded area twice daily. In Group 2 standard Nitrofurazone ointment was applied on the wounded area twice daily. In Group 3 (Test 1) S. aegyptiaca ointment (5%) and Group 4 (Test 2) S. aegyptiaca ointment (10%) was applied on the wounded area twice daily. Wound healing parameters like percent wound contraction and histopathological changes were examined in an excision wound model. The application of S. aegyptiaca ointment accelerates the healing wound contraction. Histopathological examination of granulation tissue showed much advanced phase of healing, late fibroblastic phase consisted of the presence of thrombus; minimal number of inflammatory cells, minimal to marked amount of fibrous granulation tissue, minimal to moderate amount of vascular granulation tissue and minimal to moderate reepithelialisation. The results of the study suggest that S. aegyptiaca ointment significantly enhanced and accelerated the rate of wound healing process in wounded rats.
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How to cite this article:

Nata Rajan Livingston Raja and Krishnan Sundar, 2015. Promotion of Wound Healing by Leaf Extracts of Sesbania aegyptiaca in Albino Rats. Research Journal of Medicinal Plants, 9: 116-126.

DOI: 10.3923/rjmp.2015.116.126

URL: https://scialert.net/abstract/?doi=rjmp.2015.116.126

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