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Research Journal of Medicinal Plants

Year: 2015 | Volume: 9 | Issue: 1 | Page No.: 1-13
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Authors

Rita Garcia

Joao Pinto Ferreira

Gustavo Costa

Telmo Santos

Fabio Branco

Margarida Caramona

Rui de Carvalho

Augusto Manuel Dinis

Maria Teresa Batista

Margarida Castel- Branco

Isabel V. Figueiredo

Keywords

Cymbopogon citratus is one of the most common herbs used in folk medicine due to its anti-inflammatory and antioxidant properties. Taking into account these properties showed on in vitro assays, the aim of this study was to evaluate the anti-inflammatory and analgesic activities of C. citratus leaves infusion (CcE) and its flavonoid-rich (CcF) and tannin-rich (CcT) fractions. The evaluation of the anti-inflammatory activity was performed in the carrageenan-induced rat paw oedema model. Both central and peripheral analgesic activities were evaluated in mice through the hot plate test and the acetic acid-induced writhing test, respectively. In the acute inflammation model, the statistically significant results obtained in percentage of oedema inhibition were 70.80 and 82.30% for CcE (34.12 and 68.24 mg kg-1, respectively), 59.00% for CcF (7.42 mg kg-1), 61.00% for CcT (5.96 mg kg-1) and 84.00% for positive control group (10 mg kg-1). For the peripheral pain evaluation, statistically significant results showed a pain reduction of 57.00% for CcE (136.48 mg kg-1), 54.60% for CcF (14.8 mg kg-1), 52.20% for CcT (11.92 mg kg-1) and 83.00% for positive control group. This study demonstrates that C. citratus infusion compounds are able to reduce inflammation and peripheral pain in vivo, with polyphenols showing a significant contribution for these activities.
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Rita Garcia, Joao Pinto Ferreira, Gustavo Costa, Telmo Santos, Fabio Branco, Margarida Caramona, Rui de Carvalho, Augusto Manuel Dinis, Maria Teresa Batista, Margarida Castel- Branco and Isabel V. Figueiredo, 2015. Evaluation of Anti-inflammatory and Analgesic Activities of Cymbopogon citratus In vivo-Polyphenols Contribution. Research Journal of Medicinal Plants, 9: 1-13.

URL: https://scialert.net/abstract/?doi=rjmp.2015.1.13

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