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Research Journal of Medicinal Plants
  Year: 2014 | Volume: 8 | Issue: 2 | Page No.: 82-91
DOI: 10.3923/rjmp.2014.82.91
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Antigonadal Effects of Terminalia arjuna in Male Albino Rats

Alok Chattopadhyay, Ronojoy Sengupta and Shaba Parveen

Terminalia arjuna is a well-known medicinal plant for its antidysentric, antipyretic, astringent, gastroprotective, hypocholesterolemic and cardiotonic properties. Conversely, antispermatogenic effect of this plant has also been reported. The aim of this study is to evaluate the effects of bark extract of this plant on gonadal steroidogenesis, spermatogenesis and plasma gonadotrophin (FSH and LH) levels in male albino rats. Wistar strain adult rats were administered orally with alcoholic extract of its bark dissolved in distilled water at the dose of 150 mg kg-1 day-1 for 7, 14 and 21 days. Testicular steroidogenesis was evaluated by spectrophotometric assay of the activities of 17β-hydroxysteroid dehydrogenase (17-β HSD) and Δ5-3β hydroxysteroid dehydrogenase (Δ5-3β HSD) and radioimmunoassay of plasma testosterone level. Plasma FSH and LH levels were also determined by radioimmunoassay. Spermatogenic activity was evaluated by counting the germ cells at stage VII of seminiferous cycle. Treatment for 21 days led to significant decrease in the activities of steroidogenic enzymes, plasma testosterone level and gametogenic activity. These parameters showed non-significant changes in the 7 and 14 days treatment group and no significant change was found in plasma gonadotrophin levels at any of the above durations. Though the exact mechanism of this antigonadal effect cannot be determined from the present study, one of the active constituents, β-sitosterol (a phytosterol) might be involved in this inhibition. Moreover, since treatment at the above dose and duration caused this effect, these data may have some clinical implication. Therefore, during its long-term medicinal use this adverse effect should be given due importance.
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How to cite this article:

Alok Chattopadhyay, Ronojoy Sengupta and Shaba Parveen, 2014. Antigonadal Effects of Terminalia arjuna in Male Albino Rats. Research Journal of Medicinal Plants, 8: 82-91.

DOI: 10.3923/rjmp.2014.82.91






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