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Cytotoxicity of Some Edible Plants toward Ehrlich Ascites Carcinoma Cells |
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Alvard Antonyan,
Svetlana Sharoyan,
Hayk Harutyunyan,
Naira Movsisyan,
Yelizaveta Sargisova,
Hasmik Stepanyan and Sona Mardanyan |
Abstract:
The goal of this study was to perform some contribution into the knowledge
on the antitumor ability of plants, traditionally used in folk medicine in Armenia.
The water and ethanol extracts of dried leaves of grape, sorrel and sea buckthorn,
rose petals, melilot, pellicles of walnut kernels were prepared. Their ability
to suppress the growth of cultivated mice Ehrlich Ascites Carcinoma (EAC) cells
and Mice Peripheral Blood Leukocytes (MBL) was screened. The ethanol extracts
of rose petals, grape and sorrel leaves were fractionated by gel-filtration.
The extracts and obtained fractions were characterized by antioxidant activity,
qualitative chemical analysis, thin layer chromatography and UV-Vis absorbance.
The IC50 values for inhibition of EAC cells’
growth by ethanol extracts of the three plants were evaluated and appeared in
nano-gram range. IC50 values for DPPH and ABTS radicals’
scavenging by ethanol extracts were evaluated. The antioxidant activities of
the three studied extracts of plants were in the order: rose petals>grape
leaves>sorrel leaves. The most of phenol glycosides from the three plants
with strong cytotoxicity toward EAC cells and practically no effect on the MBLs,
possessed relatively lower antioxidant activity. The strong toxicity of the
extract of sorrel leaves as a whole and of its phenol glycoside and anthracene
derivative fractions to EAC cells and low action on MBLs underlined the preference
of sorrel leaves as an anticancer remedy. Based on the obtained results, it
can be assumed that the extracts of the studied plants and their constituents
may be recommended as sources for anticancer drugs.
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How to cite this article:
Alvard Antonyan, Svetlana Sharoyan, Hayk Harutyunyan, Naira Movsisyan, Yelizaveta Sargisova, Hasmik Stepanyan and Sona Mardanyan, 2014. Cytotoxicity of Some Edible Plants toward Ehrlich Ascites Carcinoma Cells. Research Journal of Medicinal Plants, 8: 20-31.
DOI: 10.17311/rjmp.2014.20.31
URL: https://scialert.net/abstract/?doi=rjmp.2014.20.31
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