Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2014 | Volume: 8 | Issue: 3 | Page No.: 140-148
DOI: 10.3923/rjmp.2014.140.148
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Effects of Plumeria alba Roots Hydro Alcoholic Extract on some Parameters of Type 2 Diabetes
Kadebe Zoua, Bakoma Batomayena, Metowogo Kossi, Poevi Lawson-Evi, Eklu-Gadegbeku Kwashie, Aklikokou Kodjo and Gbeassor Messanvi

Abstract:
In Togo folk medicine, water infusion of Plumeria alba (Apocynaceae) root has a reputation for the local management and treatment for type 2 diabetes. The present study was investigated to evaluate the effect of Plumeria alba hydro alcoholic extract on some markers of metabolic syndrome in type 2 diabetes (hyperlipidemia, glucose intolerance, obesity) and atherogenic index. This syndrome was induced by high fructose and fat diet in male Wistar rat. The rats received fructose and fat diet (10 mL kg-1 per day) during 35 days; at the 21st day to the 35th day, 30 min before, they received distilled water for high fructose and fat diet control group, metformin 100 mg kg-1 per day or extract 250 and 500 mg kg-1 per day for treatment group. The normal control group received only distilled water during the experiment. After 5 weeks of experiment, fasting blood glucose, body weight gain, intra abdominal grease, serum triglycerides (TG), total cholesterol levels and atherogenic index in treated groups were significant (p<0.01) lower than that of high-fructose diet control group. However rats in treated group were found to have a significant (p<0.01) increase of serum HDL cholesterol level. In the oral glucose tolerance test, rats in treated group had a significant (p<0.001) reduction of blood glucose level during 180 min after glucose load, indicating that Plumeria alba root improved glucose tolerance. In conclusion, our plant can prevent metabolic syndrome induced by high fructose diet and cardiovascular diseases in type 2 diabetes. These results justify the use of Plumeria alba traditionally in the treatment of diabetes.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Preventive Effect of Bridelia ferruginea Against High-fructose Diet Induced Glucose Intolerance, Oxidative Stress and Hyperlipidemia in Male Wistar Rats
  •    Lipid Lowering Activity of Globimetula braunii
How to cite this article:

Kadebe Zoua, Bakoma Batomayena, Metowogo Kossi, Poevi Lawson-Evi, Eklu-Gadegbeku Kwashie, Aklikokou Kodjo and Gbeassor Messanvi, 2014. Effects of Plumeria alba Roots Hydro Alcoholic Extract on some Parameters of Type 2 Diabetes. Research Journal of Medicinal Plants, 8: 140-148.

DOI: 10.3923/rjmp.2014.140.148

URL: https://scialert.net/abstract/?doi=rjmp.2014.140.148

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

       

       

Curve Bottom