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Research Journal of Medicinal Plants
  Year: 2013 | Volume: 7 | Issue: 1 | Page No.: 48-57
 
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In vivo Assessment of Antidiabetic and Antioxidant Activities of Blumea balsamifera in Streptozotocin-diabetic Rats

Kalyan Roy, Shubhankar Saha, Subhasis Biswas, Wasif Ahmed and G. Mariappan

Abstract:
Blumea balsamifera Linn. (Compositae) commonly known as ‘Sambong’ is a thorny deciduous tree grown in tropical Asia and a few species in Australia and Africa. In India, its leaves are traditionally used for diabetes mellitus. The present study was aimed to evaluate the antidiabetic and in vivo antioxidant property of the leaves of Blumea balsamifera in streptozotocin (STZ) induced diabetic rats. Administration of hydro-ethanolic leaves extract of Blumea balsamifera (HEBB) in doses of 300 and 600 mg kg-1 to the Streptozotocin (STZ) induced diabetic rats showed significant reduction in blood glucose compared to diabetic control rats. Glibenclamide (5 mg kg-1 b.wt.; p.o.) was used as reference drug. Both the doses of HEBB treated diabetic rats showed a significant alteration in elevated lipid profile level along with serum marker enzyme. Antioxidant potential of HEBB was evaluated by measuring Glutathione (GSH) and Catalase (CAT) levels. Results obtained showed significant increase in GSH and CAT when compared to diabetic control group. This could explain the basis for use of Blumea balsamifera (L.) extract to manage diabetic mellitus.
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How to cite this article:

Kalyan Roy, Shubhankar Saha, Subhasis Biswas, Wasif Ahmed and G. Mariappan, 2013. In vivo Assessment of Antidiabetic and Antioxidant Activities of Blumea balsamifera in Streptozotocin-diabetic Rats. Research Journal of Medicinal Plants, 7: 48-57.

URL: https://scialert.net/abstract/?doi=rjmp.2013.48.57

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