• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Research Journal of Medicinal Plants
  2. Vol 5 (5), 2011
  3. 596-604
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Research Journal of Medicinal Plants

Year: 2011 | Volume: 5 | Issue: 5 | Page No.: 596-604

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 251

Authors


N.S. Gill

Country: India

K. Dhiman

Country: India

P. Sharma

Country: India

J. Bajwa

Country: India

S. Sood

Country: India

P.D. Sharma

Country: India

B. Singh

Country: India

M. Bali

Country: India

Keywords


  • Benincasa hispida
  • pyloric ligation
  • water immersion stress
  • NSAID
  • ulcer index
Research Article

Evaluation of Free Radical Scavenging and Antiulcer Potential of Methanolic Extract of Benincasa hispida Seeds

N.S. Gill, K. Dhiman, P. Sharma, J. Bajwa, S. Sood, P.D. Sharma, B. Singh and M. Bali
In the present study free radical scavenging and antiulcer potential of Benincasa hispida seeds was evaluated. The powdered seeds were extracted with methanol. The extract was evaluated for its free radical scavenging activity by DPPH method followed by antiulcer activity using pyloric ligation, water immersion stress and NSAID (indomethacin) induced gastric ulcer model (NIU) in rats. The parameters assessed were gastric volume, free acidity, total acidity, ulcer index and percentage ulcer protection. Ranitidine was used as the reference antiulcer drug. The methanolic extract showed concentration dependent DPPH radical scavenging activity. The methanolic extract of Benincasa hispida seeds (MEBH) inhibited gastric ulceration by decreasing the gastric volume, free and total acidity. The high dose (300 mg kg-1) showed significant reduction in the above parameters which was comparable to the standard drug ranitidine (p<0.05). The MEBH caused 52.7, 67.4 and 61.2% inhibition of ulcers in pyloric ligation, water immersion stress and NSAID induced ulcer models, respectively at 300 mg kg-1. Thus it can be concluded that the seeds of Benincasa hispida possess potent antiulcer activity. The antiulcer action may be exerted through free radical scavenging mechanism.
PDF Fulltext XML References Citation

How to cite this article

N.S. Gill, K. Dhiman, P. Sharma, J. Bajwa, S. Sood, P.D. Sharma, B. Singh and M. Bali, 2011. Evaluation of Free Radical Scavenging and Antiulcer Potential of Methanolic Extract of Benincasa hispida Seeds. Research Journal of Medicinal Plants, 5: 596-604.

URL: https://scialert.net/abstract/?doi=rjmp.2011.596.604

Related Articles

Synthetic Studies of Novel Azaflavanone Derivatives and its Biological Activities
Evaluation of Ethanolic Seed Extract of Lagenaria siceraria for Their Therapeutic Potential
Evaluation of Antioxidant, Antiulcer Activity of 9-beta-methyl-19-norlanosta-5-ene Type Glycosides from Cucumis sativus Seeds
Antioxidant and Anti-Ulcerogenic Activity of Wild Punica granatum Ethanolic Seed Extract
Phytopharmacological Evaluation of Ethanolic Extract of the Seeds of Abrus precatorius Linn
Evaluation of Antioxidant and Antiulcer Potential of Cucumis sativum L. Seed Extract in Rats
Cardioprotective Activity of Fruit of Lagenaria siceraria (Molina) Standley on Doxorubicin Induced Cardiotoxicity in Rats
Evaluation of Free Radical Scavenging, Anti-inflammatory and Analgesic Potential of Benincasa hispida Seed Extract
Study on Cucumis melo var. utilissimus Seeds for the Therapeutic Potential
Evaluation of Antioxidant and Antiulcer Activity of Traditionally Consumed Cucumis melo Seeds

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved