Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2011 | Volume: 5 | Issue: 2 | Page No.: 180-188
DOI: 10.3923/rjmp.2011.180.188
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Effects of Aqueous Extracts of Leptadenia hastata (Pers.) Decne. (Asclepediaceae) on Male Reproductive Functions Using Castrated Immature Rats

B. Bayala, M.T. Pellicer-Rubio, I.H.N. Bassole, R. Belemtougri, H.H. Tamboura and B. Malpaux

Abstract:
The present study investigated the effect of aqueous extracts of Leptadenia hastata on male reproductive function. For acute toxicity nine groups of 6 male mice received orally, respectively 50, 100, 200, 500, 1000, 1500, 2000, 3000 and 4000 mg kg-1 of L. hastata aqueous extracts. The results showed the non toxic effect of L. hastata aqueous extracts. Rat weight gain and adrenals weight did not have significantly change. Seminal vesicles, prostate, levator ani plus bulbocavernosus muscles (LABC), cowpers glands, coagulant’s glands weights were significantly decreased with 200, 400, 800 mg kg-1 compared with controls. The serum testosterone level, the fructose and protein content of seminal vesicles and prostate were also significantly decreased with 200, 400, 800 mg kg-1 compared with the controls. Total protein, total cholesterol, HDL cholesterol, blood sugar and hematocrit on blood and serum did not have significantly change. Overall, these results indicate the anti-androgenic effect of L. hastata aqueous extract by Hershberger assay.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Leptadenia hastata Pers. (Decne) a Promising Source for Natural Compounds in Biomedical Applications
  •    A Review on the Recent Advances in Pharmacological Studies on Medicinal Plants; Animal Studies are Done but Clinical Studies Needs Completing
  •    Anti-spermatogenic Activity of Leptadenia hastata (Pers.) Decne Leaf Stems Aqueous Extracts in Male Wistar Rats
How to cite this article:

B. Bayala, M.T. Pellicer-Rubio, I.H.N. Bassole, R. Belemtougri, H.H. Tamboura and B. Malpaux, 2011. Effects of Aqueous Extracts of Leptadenia hastata (Pers.) Decne. (Asclepediaceae) on Male Reproductive Functions Using Castrated Immature Rats. Research Journal of Medicinal Plants, 5: 180-188.

DOI: 10.3923/rjmp.2011.180.188

URL: https://scialert.net/abstract/?doi=rjmp.2011.180.188

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

Curve Bottom