Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2009 | Volume: 3 | Issue: 2 | Page No.: 34-40
DOI: 10.3923/rjmp.2009.34.40
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Evaluation of the Uterotonic Activity of the Aqueous Leaf Extract of Ficus exasperata Vahl (Moraceae)

Enitome E. Bafor, Eric K. Omogbai and Raymond I. Ozolua

Abstract:
The leaves of Ficus exasperata Vahl Enum. Pl. vahl (Moraceae) are used by traditional healers in Southern Nigeria to arrest preterm contractions in pregnant women and are also used as abortifacients in some parts of Africa. In this study the purported uterotonic activity of the aqueous leaf extract of F. exasperata (AET) was investigated in vitro. AET was obtained from the fresh leaves of the plant. The effect of the extract on rhythmic spontaneous uterine contractions was investigated and the extract was also directly tested on uterine tissues. The effect of the extract was compared with those of acetylcholine. The extract, at concentrations ranging from 2.5x10-2 to 100x10-2 mg mL-1, significantly increased the frequency (p<0.05) but not the amplitude of spontaneous contractions and directly stimulated uterine contractions. Acetylcholine likewise, concentration-dependently stimulated uterine contractions and significantly increased the frequency (p<0.05) of spontaneous contractions. The aqueous leaf extract of F. exasperata at the concentrations used in this study stimulates uterine contractility which may account for its use in easing childbirth in some parts of Africa.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Enitome E. Bafor, Eric K. Omogbai and Raymond I. Ozolua, 2009. Evaluation of the Uterotonic Activity of the Aqueous Leaf Extract of Ficus exasperata Vahl (Moraceae). Research Journal of Medicinal Plants, 3: 34-40.

DOI: 10.3923/rjmp.2009.34.40

URL: https://scialert.net/abstract/?doi=rjmp.2009.34.40

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

Curve Bottom