Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Research Journal of Medicinal Plants
  Year: 2009 | Volume: 3 | Issue: 4 | Page No.: 123-133
DOI: 10.3923/rjmp.2009.123.133
Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat
S. Sood, S. Bansal, A. Muthuraman, N.S. Gill and M. Bali

Abstract: In this study, we planned to evaluate the antioxidative, anti-inflammatory and analgesic potential of Citrus medica peel extract. Antioxidant activity in different solvent systems was evaluated. Ethyl acetate extract of Citrus medica peel (EtCM) showed maximum 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide radical scavenging activity in a dose dependent manner as compared to ascorbic acid. Further, anti-inflammatory and analgesic activities of EtCM (200, 300 and 400 mg kg-1) were studied on carrageenan induced inflammatory pain in rats. Anti-inflammatory activity was assessed by measuring paw volume in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions by using hot plate, plantar, pin prick and mechanical allodynia tests in rats. EtCM (400 mg kg-1) produced significant decrease in paw volume and pain as compared to diclofenac. Therefore, the Citrus medica peel extract may be used as a future antioxidant for the treatment of inflammation and pain.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Evaluation of Antioxidant and Antiulcer Potentials of Prunus domestica Fruit Methanolic and Extract on Wistar Albino Rats
  •    Relative Anti-inflammatory and Analgesic Activities of the Whole Fruit, Fruit Bark, Pulp and Seed of Lagenaria breviflora Roberty
  •    Evaluation of Antioxidant, Antiulcer Activity of 9-beta-methyl-19-norlanosta-5-ene Type Glycosides from Cucumis sativus Seeds
  •    Antioxidant Activity and Pharmacological Evaluation of Cucumis melo var. agrestis Methanolic Seed Extract
How to cite this article:

S. Sood, S. Bansal, A. Muthuraman, N.S. Gill and M. Bali, 2009. Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat. Research Journal of Medicinal Plants, 3: 123-133.

DOI: 10.3923/rjmp.2009.123.133

URL: https://scialert.net/abstract/?doi=rjmp.2009.123.133
 
COMMENT ON THIS PAPER
 
 
 

 
  Navigation
 
  Online First
  Current Issue
  Previous Issues
  Editorial Board
  Submit a Manuscript
  Guide to Authors
  Subscribe to E-alerts

  Indexed In
 
  ASCI-Database
  Asian Digital Library
  Google Scholar

       

       

Science Alert
Curve Bottom