Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat

Research Article

**Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat**

S. Sood, S. Bansal, A. Muthuraman, N.S. Gill and M. Bali

In this study, we planned to evaluate the antioxidative, anti-inflammatory and analgesic potential of Citrus medica peel extract. Antioxidant activity in different solvent systems was evaluated. Ethyl acetate extract of Citrus medica peel (EtCM) showed maximum 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydrogen peroxide radical scavenging activity in a dose dependent manner as compared to ascorbic acid. Further, anti-inflammatory and analgesic activities of EtCM (200, 300 and 400 mg kg^-1) were studied on carrageenan induced inflammatory pain in rats. Anti-inflammatory activity was assessed by measuring paw volume in rats. Analgesic activity was evaluated for its central and peripheral pharmacological actions by using hot plate, plantar, pin prick and mechanical allodynia tests in rats. EtCM (400 mg kg^-1) produced significant decrease in paw volume and pain as compared to diclofenac. Therefore, the Citrus medica peel extract may be used as a future antioxidant for the treatment of inflammation and pain.

PDF Fulltext XML References Citation

How to cite this article

S. Sood, S. Bansal, A. Muthuraman, N.S. Gill and M. Bali, 2009. Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat. Research Journal of Medicinal Plants, 3: 123-133.

URL: https://scialert.net/abstract/?doi=rjmp.2009.123.133

Research Journal of Medicinal Plants

Article Trend

Total views 847

Search

Authors

S. Sood

S. Bansal

A. Muthuraman

N.S. Gill

M. Bali

Keywords

Research Article

**Therapeutic Potential of Citrus medica L. Peel Extract in Carrageenan Induced Inflammatory Pain in Rat**

How to cite this article

Related Articles

Leave a Comment