• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Research Journal of Medicinal Plants
  2. Vol 3 (3), 2009
  3. 102-108
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Research Journal of Medicinal Plants

Year: 2009 | Volume: 3 | Issue: 3 | Page No.: 102-108

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 248

Authors


A.A.A. Kayode

Country: Nigeria

O.T. Kayode

Country: Nigeria

A.A. Odetola

Country: Nigeria

Keywords


  • Parquetina nigrescens
  • antioxidant enzymes
  • mucosa
  • antiulcer activity
  • free radicals
Research Article

Anti-Ulcerogenic Activity of Two Extracts of Parquetina nigrescens and their Effects on Mucosal Antioxidants Defence System on Ethanol-Induced Ulcer in Rats

A.A.A. Kayode, O.T. Kayode and A.A. Odetola
The effect of two extracts of Parquetina nigrescens on mucosal antioxidants defense system in ethanol-induced ulcer in rats was studied. Activities of superoxide dismutase (SOD), catalase (CAT) and levels of reduced glutathione (GSH) were determined in the gastric mucosa and liver of normal and experimental groups of rats. The rats were pretreated with 500 and 1000 mg kg-1 of hexane and chloroform extracts of P. nigrescens, respectively dissolved in olive oil for a period of 14 days prior to ethanol induction. It was found that prior to ulcer induction, 14 days pretreatment with hexane and chloroform extract P. nigrescenes significantly reduced ethanol-induced gastric damage. The levels of GSH and activities of the antioxidants enzymes (SOD and CAT) were depressed significantly (p<0.05) in the ulcerated rats when compared with that of normal control. The activity of SOD was lower significantly (p<0.05) in the ulcerated mucosa and liver of the experimental rats when compared to the normal control group. There was a significant increase (p<0.05) in the level of CAT in the groups pretreated with the extracts compared to the ethanol group. A similar result was observed for GSH. Pretreatment with hexane extract caused 75.43 and 74.55% elevations in the activities of SOD in the mucosa and liver homogenate, respectively. Similar elevations were observed in the group pretreated with the chloroform extract. The cimetidine group also caused 69.79 and 69.67% elevation in the SOD activity in the mucosa and liver homogenate, respectively. The pretreatment with P. nigrescens was found to exact a significant gastro protective and antiulcer effect partly by protecting against the ethanol-induced ulcerogenic effects in experimental rats and probably through the induction of antioxidant enzymes.
PDF Fulltext XML References Citation

How to cite this article

A.A.A. Kayode, O.T. Kayode and A.A. Odetola, 2009. Anti-Ulcerogenic Activity of Two Extracts of Parquetina nigrescens and their Effects on Mucosal Antioxidants Defence System on Ethanol-Induced Ulcer in Rats. Research Journal of Medicinal Plants, 3: 102-108.

URL: https://scialert.net/abstract/?doi=rjmp.2009.102.108

Related Articles

Medicinal Plants Used in the Treatment of Gastric Ulcer in Southwestern and North Central Nigeria
Parquetina nigrescens Checks the Ulceration and Oxidation
Lentinus sp. RJ-2 Mushroom is Important Source of Natural Antioxidative Polysaccharides
Parquetina nigrescens Checks the Ulceration and Oxidation
Effects of Oral Administration of Antioxidant Taurine on Haematological Parameters in Wistar Rats

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved