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Research Journal of Medicinal Plants
  Year: 2008 | Volume: 2 | Issue: 1 | Page No.: 22-27
DOI: 10.3923/rjmp.2008.22.27
 
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Role of Elephantopus scaber on the Glucose Oxidation in Liver and Skeletal Muscles of Streptozotocin (STZ) Induced Diabetic Adult Male Rats

P. Daisy and R. Jasmine

Abstract:
In type-II diabetic individuals, there is an increase in hepatic glucose production impaired insulin signaling, decreased glucose transport and phosphorylation and diminished glycogen synthesis contribute to insulin resistance in target tissues. Liver and skeletal muscles are major target sites for insulin-mediated glucose uptake, metabolism and utilization in humans. Indeed, impaired insulin action in liver and skeletal muscles is responsible for the majority of the decreased levels of non-oxidative glucose disposal observed in type II diabetes. The influences of Elephantopus scaber (ES) (roots and leaves) on glucose oxidation in liver and skeletal muscles were studied. The present study shows that E. scaber extracts have a positive role in glucose oxidation and corrects the metabolic alterations caused by diabetes effectively. A significant reduction in the blood glucose levels and a corresponding increase in the serum insulin levels further proves the hypoglycemic activity of the plant by oxidation of glucose. These observed effects of E. scaber on glucose oxidation in liver and skeletal muscles are comparable to the effects of insulin and suggest a possible therapeutic effect of E. scaber on glucose oxidation in diabetes. Further studies on the isolation of active compounds and determining their mode of action would be of great interest.
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How to cite this article:

P. Daisy and R. Jasmine, 2008. Role of Elephantopus scaber on the Glucose Oxidation in Liver and Skeletal Muscles of Streptozotocin (STZ) Induced Diabetic Adult Male Rats. Research Journal of Medicinal Plants, 2: 22-27.

DOI: 10.3923/rjmp.2008.22.27

URL: https://scialert.net/abstract/?doi=rjmp.2008.22.27

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