Forkhead Box P3 Messenger-RNA Expression after Curcuma longa Extract Intervention in Early Pregnant Mice with Toxoplasmosis


	Research Journal of Immunology
	Year: 2018 \| Volume: 11 \| Issue: 1 \| Page No.: 1-6 DOI: 10.3923/rji.2018.1.6

Forkhead Box P3 Messenger-RNA Expression after Curcuma longa Extract Intervention in Early Pregnant Mice with Toxoplasmosis

Tigor Peniel Simanjuntak

, Mochammad Hatta

, Syahrul Rauf, Irawan Yusuf and Mardiah Tahir

Abstract: Background and Objective: Curcuma longa (C. Longa) has strong anti-inflammatory effect. This study aims to examine the effect of Curcuma longa extract on Forkhead Box P3 (FOXP3) mRNA expression in early pregnant mice with acute toxoplasmosis. Materials and Methods: This study evaluated 20 early pregnant mice that were divided into 5 groups, four mice in each. Group 1-4 received injections of Toxoplasma gondii tachyzoites. Three days later, G1 and G2 were given orally 125 and 500 mg kg^–1/day of Curcuma longa extract, respectively. The G3 was given 60 mg kg^–1/day of spiramycin (positive control) and G4 was given 0.2 mL of distilled water (negative control). The G5 underwent no intervention at all. Blood samples were obtained serially (before and 3 days after injection of tachyzoites, 3 and 7 days after intervention) to assess FOXP3 mRNA expression. Results: The FOXP3 mRNA expression increased significantly in G1-G3 3 days after intervention (p<0.05), whereas, FOXP3 mRNA expression decreased significantly (p<0.05) 7 days after intervention and there was no significant difference between these three groups. The FOXP3 mRNA expression in G4 increased significantly 3, 6 and 10 days after tachyzoites injections, while FOXP3 mRNA expression on G5 fluctuated but considered as insignificant (p>0.05). Conclusion: The administration of Curcuma longa extract at a dose of 125 mg kg^–1/day for 3 days effectively increased FOXP3 mRNA expression and 7 days administration resulted in decreased FOXP3 mRNA expression in early pregnant mice with acute toxoplasmosis.

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How to cite this article:

Tigor Peniel Simanjuntak, Mochammad Hatta, Syahrul Rauf, Irawan Yusuf and Mardiah Tahir, 2018. Forkhead Box P3 Messenger-RNA Expression after Curcuma longa Extract Intervention in Early Pregnant Mice with Toxoplasmosis. Research Journal of Immunology, 11: 1-6.

DOI: 10.3923/rji.2018.1.6

URL: https://scialert.net/abstract/?doi=rji.2018.1.6

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