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Research Journal of Environmental Toxicology
  Year: 2018 | Volume: 12 | Issue: 1 | Page No.: 11-17
DOI: 10.3923/rjet.2018.11.17
 
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Protective Effect of Ascorbic Acid Against Bonny Light Crude Oil Induced Atherosclerosis in Rats

Saviour Udo Ufot, Uduak Onofiok Luke, Friday Effiong Uboh and Eyong Ubana Eyong

Abstract:
Background and Objective: Crude oil has been reported to cause various toxic effects in the body. And vitamins C and E are among the antioxidants known to play important role in attenuating chemical toxicants-induced toxicities in the biological systems. This study aimed at assessing the protective effect of vitamin C against crude oil induced atherosclerosis in rats. Materials and Methods: Twenty four male albino Wistar rats, weighing 150-180 g, used in this study were distributed into four groups (1, 2, 3 and 4), with 6 rats each. Group 3 animals were orally administered 60 mg of NBLCO kg–1 b.wt., while group 4 animals were orally administered 60 mg NBLCO kg–1 b.wt. and co-administered 200.0 mg of vitamin C kg–1 b.wt., of the rats daily for 30 days. The animals in groups 1 and 2 served as the controls receiving only distilled water and vitamin C, respectively. At end of the experimental period, the animals were sacrificed and blood samples collected through cardiac puncture for plasma lipid profile analyses. Total plasma cholesterol (TC), triacylglycerol (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL) levels and atherogenic indices were determined in rats orally exposed to Nigerian Bonny light crude oil (NBLCO) and co-administered vitamin C. Results: The results of the study showed that exposure to crude oil is a risk factor for atherosclerosis by producing a significant (p<0.05) increase in plasma TC, TG, LDL and VLDL levels and the evaluated atherogenic indices (Group 3), compared to the control (Group 1). The plasma TC, TG, LDL, VLDL levels and the atherogenic indices recorded for rats exposed to NBLCO and co-administered vitamin C (Group 4) were significantly (p<0.05) lower, compared to the rats exposed to NBLCO only (Group 3). Conclusion: This study demonstrated that vitamin C is capable of providing protection against crude oil induced atherosclerotic conditions by regulating serum lipids profiles and atherogenic indices in rats. It may be concluded that vitamin C is potent in preventing cardiovascular disorders associated with crude oil induced atherosclerotic conditions.
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How to cite this article:

Saviour Udo Ufot, Uduak Onofiok Luke, Friday Effiong Uboh and Eyong Ubana Eyong, 2018. Protective Effect of Ascorbic Acid Against Bonny Light Crude Oil Induced Atherosclerosis in Rats. Research Journal of Environmental Toxicology, 12: 11-17.

DOI: 10.3923/rjet.2018.11.17

URL: https://scialert.net/abstract/?doi=rjet.2018.11.17

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