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Research Journal of Environmental Toxicology
  Year: 2010 | Volume: 4 | Issue: 3 | Page No.: 134-140
DOI: 10.3923/rjet.2010.134.140
 
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Haematotoxic Effects of Diets Contaminated with Petroleum Products (Kerosene and Petrol) in Wistar Albino Rats

K.C. Patrick-Iwuanyanwu, C.C. Onyemaenu, M.O. Wegwu and E.O. Ayalogu

Abstract:
Haematotoxic effects following administration of kerosene and Petrol-contaminated diets were investigated in male and female albino rats. Haematological parameters namely haemoglobin (Hb), Packed Cell Volume (PCV), White Blood Cell Counts (WBC) and differentials were used to assess the effect of kerosene and petrol-contaminated diets on rats. LD50 values of kerosene and petrol were obtained at levels of 212 and 128 mL kg-1 of feed respectively for 12 weeks. Long term exposure of the animals to kerosene and petrol-contaminated diets caused a significant decrease (p≤0.05) in PCV and Hb indicating an anaemic condition. Male and female rats fed diets contaminated with kerosene and petrol showed a significant decrease (p≤0.05) in the WBC counts. Result of the differential count showed a significant increase (p≤0.05) in neutrophils of male and female rats fed diets contaminated with kerosene and petrol while lymphocytes, antibody forming leucocytes decreased significantly (p≤0.05) among rats fed diets contaminated with kerosene and petrol indicating a response to stress and susceptibility of the animals to infection. Long term exposure of rats to kerosene and petrol-contaminated diets induced anaemia as observed in this study.
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How to cite this article:

K.C. Patrick-Iwuanyanwu, C.C. Onyemaenu, M.O. Wegwu and E.O. Ayalogu, 2010. Haematotoxic Effects of Diets Contaminated with Petroleum Products (Kerosene and Petrol) in Wistar Albino Rats. Research Journal of Environmental Toxicology, 4: 134-140.

DOI: 10.3923/rjet.2010.134.140

URL: https://scialert.net/abstract/?doi=rjet.2010.134.140

COMMENTS
24 September, 2010
Ogbonnaya Lawrence N:
I am working on the effect of crude oil on the lipid profile of albino rats in my undergraduate project work. I must say that this work is well done.
From Biochemistry Dept.
Federal University of Technology, Owerri
28 June, 2019
SANGARI JOEL SUNDAY:
I am working on the effects of ingested kerosene contaminated diets on the kidney and liver of albino rats. This work is well doned and also help me in my study.
I want to solicit similar journals to my work pls
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