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Research Journal of Environmental Sciences

Year: 2018 | Volume: 12 | Issue: 2 | Page No.: 53-62
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Authors

Anthony Cemaluk Chinedum Egbuonu

Anthony Cemaluk Chinedum Egbuonu

Chinazum Immaculate Opara

Doris Akachukwu

Uchechi Bliss Onyedikachi

Keywords

Background and Objective: Continuous search for non-toxic natural products that could mitigate possible MSG-induced effects including on hepatic histo-morphology and functional capacity of animals. This study aimed to determine the effect of ethanolic extract of avocado pear (Persea americana) seeds (ASE) on normal and monosodium glutamate (MSG)-compromised rats’ liver. Methodology: After 14 days daily oral exposure of rats to ASE and MSG either alone or combined, changes in the rats’ liver histology and serum bio-indicators were assessed using standard protocols. Data were analyzed by one-way ANOVA using SPSS. Results: Serum alanine aminotransferase, ALT, (360.00 and 31.58%) and aspartate aminotransferase, AST, (176.77 and 04.46%) activities in the high-extract co-treated-group increased (p<0.05) above the others relative to control or MSG-group but decreased (p<0.05) more in ASE-group (07.03%, ALT, (43.50%, AST) relative to MSG-group. A similar trend was noted in the serum alkaline phosphatase (ALP) activity, protein concentration and the computed ratios (ALT:AST, AST:ALP, ALT:ALP and the respective corollary) of the rats while the highest increase and decrease in total bilirubin concentration relative to MSG-group was respectively in the medium-extract co-treated-group and in the ASE alone-group. Preserved hepatic histo-morphology with normal blood flow devoid of central vein congestion noted in the control and ASE alone-group contrasted the full central vein congestion in the MSG-group. Apparently reduced central vein congestion in the liver sections of rats co-exposed to MSG and low ASE dose was not sustained at either medium or high ASE concentration, seemingly confirming the serum chemistry observations. Conclusion: Thus, the study demonstrated a non-definitive influence of ASE alone and overriding adverse influence of MSG either alone or together with ASE on the hepatic histo-morphology and serum bio-functional indicators of the liver and perhaps other high metabolic organs.
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How to cite this article

Anthony Cemaluk Chinedum Egbuonu, Chinazum Immaculate Opara, Doris Akachukwu and Uchechi Bliss Onyedikachi, 2018. Effect of Ethanolic Extract of Avocado Pear (Persea americana) Seed on Normal and Monosodium Glutamate-compromised Rats' Hepatic Histo-morphology and Serum Bio-functional Parameters. Research Journal of Environmental Sciences, 12: 53-62.

DOI: 10.3923/rjes.2018.53.62

URL: https://scialert.net/abstract/?doi=rjes.2018.53.62

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