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Research Journal of Environmental Sciences
  Year: 2018 | Volume: 12 | Issue: 2 | Page No.: 53-62
DOI: 10.3923/rjes.2018.53.62
 
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Effect of Ethanolic Extract of Avocado Pear (Persea americana) Seed on Normal and Monosodium Glutamate-compromised Rats' Hepatic Histo-morphology and Serum Bio-functional Parameters

Anthony Cemaluk Chinedum Egbuonu , Chinazum Immaculate Opara, Doris Akachukwu and Uchechi Bliss Onyedikachi

Abstract:
Background and Objective: Continuous search for non-toxic natural products that could mitigate possible MSG-induced effects including on hepatic histo-morphology and functional capacity of animals. This study aimed to determine the effect of ethanolic extract of avocado pear (Persea americana) seeds (ASE) on normal and monosodium glutamate (MSG)-compromised rats’ liver. Methodology: After 14 days daily oral exposure of rats to ASE and MSG either alone or combined, changes in the rats’ liver histology and serum bio-indicators were assessed using standard protocols. Data were analyzed by one-way ANOVA using SPSS. Results: Serum alanine aminotransferase, ALT, (360.00 and 31.58%) and aspartate aminotransferase, AST, (176.77 and 04.46%) activities in the high-extract co-treated-group increased (p<0.05) above the others relative to control or MSG-group but decreased (p<0.05) more in ASE-group (07.03%, ALT, (43.50%, AST) relative to MSG-group. A similar trend was noted in the serum alkaline phosphatase (ALP) activity, protein concentration and the computed ratios (ALT:AST, AST:ALP, ALT:ALP and the respective corollary) of the rats while the highest increase and decrease in total bilirubin concentration relative to MSG-group was respectively in the medium-extract co-treated-group and in the ASE alone-group. Preserved hepatic histo-morphology with normal blood flow devoid of central vein congestion noted in the control and ASE alone-group contrasted the full central vein congestion in the MSG-group. Apparently reduced central vein congestion in the liver sections of rats co-exposed to MSG and low ASE dose was not sustained at either medium or high ASE concentration, seemingly confirming the serum chemistry observations. Conclusion: Thus, the study demonstrated a non-definitive influence of ASE alone and overriding adverse influence of MSG either alone or together with ASE on the hepatic histo-morphology and serum bio-functional indicators of the liver and perhaps other high metabolic organs.
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How to cite this article:

Anthony Cemaluk Chinedum Egbuonu, Chinazum Immaculate Opara, Doris Akachukwu and Uchechi Bliss Onyedikachi, 2018. Effect of Ethanolic Extract of Avocado Pear (Persea americana) Seed on Normal and Monosodium Glutamate-compromised Rats' Hepatic Histo-morphology and Serum Bio-functional Parameters. Research Journal of Environmental Sciences, 12: 53-62.

DOI: 10.3923/rjes.2018.53.62

URL: https://scialert.net/abstract/?doi=rjes.2018.53.62

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