Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Research Journal of Cardiology
  Year: 2011 | Volume: 4 | Issue: 1 | Page No.: 16-27
DOI: 10.3923/rjc.2011.16.27
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
The Effect of Hormone Replacement Therapy with or without Folic Acid on Homocysteine Level as Risk Factor for Cardiovascular Disease in Postmenopausal Female Rats
N.S. AL-Sowyan

Abstract:
This study was conducted to investigate the effect of menopause induced by ovariectomy of rats on serum level of some cardiovascular risk factors such as lipid profile and homocysteine (Hcy) as new risk factor for cardiovascular disease specially the coronary artery disease. Moreover, to determine whether supplementation of estrogen hormone as a replacement therapy or folic acid could be modulate the effects of ovariectomy on the previous parameters or not? Fifty adult female albino rats were divided into five equal groups: group one served as control, the rats in the second group were subjected to ovariectomy, the third group were exposed to ovariectomy and treated with estrogen, the fourth group were ovariectomized and supplemented with folic acid and the fifth group were consist of ovariectomized (ovx) rats treated with estrogen and supplemented with folic acid. Ovariectomized rats showed a significant increase in serum homocysteine, total cholesterol, LDL-c and triglycerides, with significant decrease in HDL-c levels than normal control, oral estrogen administration to ovariectomized rats, induced significant reduction of Hcy, total cholesterol, LDL-c levels than ovariectomized control group. Folic acid supplementation to ovariectomized rats revealed, significant decrease in serum Hcy, LDL-c with insignificant increase in HDL-c, while combined treatment of estrogen and folic acid resulted in significant decrease in Hcy and significant increase in triglycerides levels versus ovariectomized rats. We can conclude that supplementation of food with folic acid succeeded in alleviating the disturbances in homocysteine levels as well as lipid profile metabolism observed in ovariectomized rats.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Assessment of Nutritional Status in Post Menopausal Women of Ardebil, Iran
  •    Influences of Postmenopausal Hormone Replacement Therapy on Women`s Health
How to cite this article:

N.S. AL-Sowyan , 2011. The Effect of Hormone Replacement Therapy with or without Folic Acid on Homocysteine Level as Risk Factor for Cardiovascular Disease in Postmenopausal Female Rats. Research Journal of Cardiology, 4: 16-27.

DOI: 10.3923/rjc.2011.16.27

URL: https://scialert.net/abstract/?doi=rjc.2011.16.27

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 

       

       

Curve Bottom