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Plant Pathology Journal

Year: 2015 | Volume: 14 | Issue: 3 | Page No.: 123-129
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Authors

Anuradha Chelliah

Balasubramanian Velusamy

Selvarajan Ramasamy

Keywords

Research Article

Sequence Motif Comparison and Homology Modeling of Helper Component Proteinase (HC-Pro) of Banana bract mosaic virus

Anuradha Chelliah, Balasubramanian Velusamy and Selvarajan Ramasamy
The Helper Component Proteinase (HC-Pro) is a key protein encoded by the plant viruses of the genus potyvirus. The HC-Pro is involved in different steps of the viral cycle, aphid transmission, replication virus cell-to-cell and systemic movement and is a suppressor of post-transcriptional gene silencing. The amino acid sequence of Banana bract mosaic virus (BBrMV) HC-Pro was compared both inter and intra species across different potyviruses to demonstrate the functional correlation of sequence motifs of HC-Pro to predict its role in virus cycles. Knowledge on the structure of HC-Pro will greatly contribute to understand its multifaceted functions and how structural domains are organized to fulfill them in concert or independently hence, a stable model of BBrMV HC-Pro has been proposed based on homology modeling. The results obtained from this study will provide a framework for new hypothesis and research directions in the area of differential role of HC-Pro.
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