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Pakistan Journal of Nutrition
  Year: 2021 | Volume: 20 | Issue: 2 | Page No.: 46-54
DOI: 10.3923/pjn.2021.46.54
 
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Mechanism of Anti-Angiogenic and Renal Protective Activity of Balanites aegyptiaca Seeds Extract in Ehrlich Ascites Carcinoma-Bearing Mice

Ahmed A. Emara, Maraym F. Dawood, Wafaa A. Abdallah, Aya Z. Hazaa, Alyaa A. Ahmed, Aya S. Elbayoumy, Asmaa M. El-nossairy, Nuran S. Yaqoub, Shymaa H. Khalifa, Elshimaa O. Abdelaziz, Abdelrahman B. Khairy, Naglaa A. Gobba, Esraa A. Abdalla, Ismail Hegazy and Mohammed A. Hussein

Abstract:

Background: One of the animal angiogenesis with high inflammation and rapid growth is Ehrlich ascites carcinoma. Balanites aegyptiaca seeds extract (BASE), a new synthesized compound has antioxidant and antidiabetic activity. The purpose of this study was to evaluate anti-angiogenic activity of BASE in ehrlich ascites carcinoma (EAC)-bearing mice. Materials and Methods: BASE was prepared and characterized using instrumental analysis and spectral data. Furthermore, the IC50 of BASE against the renal carcinoma cell line (RCC-949) was calculated. Adult albino mice weighing 25±5 g was used to assess the anti-angiogenic activity of BASE (100 and 200 mg kg‾1 body weight) in EAC-bearing mice. Results: IC50 of BASE against the renal carcinoma cell line (RCC-949) was equal to 62.18 µg mL‾1. The daily oral administration of BASE at concentrations of 100 and 200 mg kg‾1 body weight for 30 days to EAC-bearing mice resulted in a significant improvement in tumor volume and tumor weight, urea, creatinine, uric acid, TNF-α, NOx, TBARs, GSH, CAT, SOD, GPx and VEGF-C gene expression in EAC-bearing mice. Furthermore, BASE almost normalized these effects in renal histoarchitecture. Conclusion: The BASE has anti-angiogenic activity in EAC-bearing mice.

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How to cite this article:

Ahmed A. Emara, Maraym F. Dawood, Wafaa A. Abdallah, Aya Z. Hazaa, Alyaa A. Ahmed, Aya S. Elbayoumy, Asmaa M. El-nossairy, Nuran S. Yaqoub, Shymaa H. Khalifa, Elshimaa O. Abdelaziz, Abdelrahman B. Khairy, Naglaa A. Gobba, Esraa A. Abdalla, Ismail Hegazy and Mohammed A. Hussein, 2021. Mechanism of Anti-Angiogenic and Renal Protective Activity of Balanites aegyptiaca Seeds Extract in Ehrlich Ascites Carcinoma-Bearing Mice. Pakistan Journal of Nutrition, 20: 46-54.

DOI: 10.3923/pjn.2021.46.54

URL: https://scialert.net/abstract/?doi=pjn.2021.46.54

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