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Pakistan Journal of Nutrition

Year: 2021 | Volume: 20 | Issue: 2 | Page No.: 37-45
DOI: 10.3923/pjn.2021.37.45

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Authors


Mona S. Abd El-Latif Shaban

Country: Egypt

Dina A. Yousif

Country: Egypt

Nada A. Ahmed

Country: Egypt

Gehad R. Abd Allah

Country: Egypt

Yasmen A. Elbagoury

Country: Egypt

Nour E. El Sayed

Country: Egypt

Hossam A. Hassan

Country: Egypt

Bassem M. El-hefnawy

Country: Egypt

Ahmed R. Nageh

Country: Egypt

El-Sayed S. Amer

Country: Egypt

Ahmed H. Mohamed

Country: Egypt

Naglaa A. Gobba

Country: Egypt

Mohammed A.  Hussein

Mohammed A. Hussein

LiveDNA: 20.9149

Keywords


  • Jasonia Montana
  • selenium nanoparticles
  • doxorubicin
  • liver toxicity
  • caspase-8
  • TNF- κB
  • IL-1β
Research Article

Protective Effects of Jasonia Montana-Selenium Nanoparticles Against Doxorubicin-Induced Liver Toxicity

Mona S. Abd El-Latif Shaban, Dina A. Yousif, Nada A. Ahmed, Gehad R. Abd Allah, Yasmen A. Elbagoury, Nour E. El Sayed, Hossam A. Hassan, Bassem M. El-hefnawy, Ahmed R. Nageh, El-Sayed S. Amer, Ahmed H. Mohamed, Naglaa A. Gobba and Mohammed A. Hussein Mohammed A.  Hussein's LiveDNA

Background and Objective: Doxorubicin administration induces hepatotoxicity by production of reactive oxygen species (ROS) and cytokines that result in imbalanced redox potential leading to oxidative stress and reduced levels of antioxidant enzymes. The purpose of this study was to evaluate the protective effect of Jasonia Montana aqueous extract-selenium Nanoparticles (JMAE-SeNPs) against Dox-induced liver toxicity in rats. Materials and Methods: JMAE-SeNPs were prepared and characterized in terms of particle size and zeta potential. Furthermore, the IC50 of JMAE-SeNPs against Hep-G2 liver carcinoma cell line and LD50 was calculated. A total of 84 adult albino rats were used to assess the liver protective activity of JMAE-SeNPs against DOX-induced liver toxicity in rats. Results: JMAE-SeNPs had size of around 25 nm with negative zeta potential of -36.8±0.62. Also, its IC50 against Hep-G2 liver carcinoma cell line and LD50 was equal to 166.78 μg mL–1 and 1120 mg kg–1 body weight, respectively. The daily oral administration of JMAE-SeNPs at concentrations of 1/50 LD50 (25 mg kg–1 body weight) and 1/20 LD50 (50 mg kg–1 body weight) for 30 days to rats treated with DOX (2.0 mg kg–1 body weight) resulted in a significant improvement in plasma ALT, AST, AST and LDH as well as liver MDA, caspase-8, TNF- κB and IL-1β. Oral administration of JMAE-SeNPs, on the other hand, increased the activity of SOD, GPx and GSH in DOX-treated rats. Furthermore, JMAE-SeNPs almost normalized these effects of DOX in liver tissue. Conclusion: The biochemical and histological findings of our study demonstrated that JMAE-SeNPs have liver protective activity against DOX-induced liver toxicity in rats.


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How to cite this article

Mona S. Abd El-Latif Shaban, Dina A. Yousif, Nada A. Ahmed, Gehad R. Abd Allah, Yasmen A. Elbagoury, Nour E. El Sayed, Hossam A. Hassan, Bassem M. El-hefnawy, Ahmed R. Nageh, El-Sayed S. Amer, Ahmed H. Mohamed, Naglaa A. Gobba and Mohammed A. Hussein, 2021. Protective Effects of Jasonia Montana-Selenium Nanoparticles Against Doxorubicin-Induced Liver Toxicity. Pakistan Journal of Nutrition, 20: 37-45.

DOI: 10.3923/pjn.2021.37.45

URL: https://scialert.net/abstract/?doi=pjn.2021.37.45

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