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Pakistan Journal of Nutrition
  Year: 2019 | Volume: 18 | Issue: 7 | Page No.: 671-676
DOI: 10.3923/pjn.2019.671.676
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Effect of Lawsonia inermis Linn. Extracts on Blood Glucose Level in Normal and Streptozotocin-Induced Diabetic Rats

T. Widyawati , Y.S. Pane and N.A. Yusoff

Background and Objective: Lawsonia inermis Linn. is one of the common medicinal plants that are being used widely to treat diabetes in Medan, North Sumatera, Indonesia. Scientific evidence to confirm its efficacy is still lacking. Hence, this study was designed to evaluate the effect of L. inermis leaf extracts on glucose level in normal and streptozotocin-induced diabetic rats. Materials and Methods: Serial extraction of Lawsonia inermis Linn. leaf was conducted to obtain the respective n-hexane (HE), ethyl acetate (EAE), ethanol (EE) and distilled water (A1E) extracts. Another water extract (A2E) was obtained using infusion technique. These extracts were administered orally at the dose of 1 g kg–1 b.w. to normal and streptozotocin-induced diabetic rats. An acute hypoglycemic, glucose tolerance and antihyperglycemic effects were assessed. Qualitative phytochemical screenings were conducted prior to the in vivo tests. Results: The phytochemical screenings revealed the presence of steroid and triterpenoid in HE, alkaloid, tannin, flavonoids, saponin and glycoside in EE and EAE. While in A1E and A2E, tannin, flavonoid, saponin and glycoside were identified. Hypoglycemic test in normal rats showed HE was able to decrease blood glucose level (BGL) significantly (p<0.05). A1E and A2E were able to inhibit the rise of BGL after being challenged with glucose intraperitoneally. Furthermore, administration of single dose of extracts showed that only EAE exerted significant antihyperglycemic activity. Conclusion: All the extracts of Lawsonia inermis Linn. leaf, except for EE, have shown certain degree of antidiabetic activity with possible different mechanisms of antidiabetic action.
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How to cite this article:

T. Widyawati, Y.S. Pane and N.A. Yusoff, 2019. Effect of Lawsonia inermis Linn. Extracts on Blood Glucose Level in Normal and Streptozotocin-Induced Diabetic Rats. Pakistan Journal of Nutrition, 18: 671-676.

DOI: 10.3923/pjn.2019.671.676






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