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Pakistan Journal of Nutrition
  Year: 2016 | Volume: 15 | Issue: 1 | Page No.: 40-44
DOI: 10.3923/pjn.2016.40.44
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Effect of Vitamin A, Zinc and Vitamin E Supplementation on Immune Response in Seropositive Leprosy Subjects
M. Zen Rahfiludin, Adriyan Pramono and Onny Setiani

The immune response plays an important role in leprosy prevention. Here we analyzed the effect of vitamin A, zinc and vitamin E supplementation on the immune response in seropositive leprosy patients by measuring serum levels of retinol, zinc, α-tocopherol, interferon gamma (IFN-γ) and interleukin-2 (IL-2). Subjects were randomly divided into either the treatment or control group. The treatment group received high dose vitamin A once and a daily dose of Zn and vitamin E supplementation for 45 days, while the control group received pills that were identical in appearance but lacked supplements. Supplement consumption compliance was recorded weekly. After 45 days of supplementation, IFN-γ and IL-2 levels were measured again. Upon study initiation both groups had normal retinol, zinc and α-tocopherol serum levels. After 45 days, serum levels of retinol and α-tocopherol increased only in the supplementation group (p = 0.046 and p = 0.033, respectively), while zinc serum levels decreased in both the supplementation (p = 0.001) and placebo (p = 0.000) groups. IFN-γ levels decreased slightly in the supplementation group, although the change was not significant (p = 0.098). Meanwhile, IFN-γ levels in the control group decreased significantly (p = 0.022). IL-2 levels decreased slightly in both the supplementation and placebo groups, but the changes were not significant (p = 0.421 and p = 0.556, respectively). Together our results indicate that supplementation with zinc and vitamins A and E could be a useful alternative therapy for maintaining immune response of seropositive leprosy patients.
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How to cite this article:

M. Zen Rahfiludin, Adriyan Pramono and Onny Setiani, 2016. Effect of Vitamin A, Zinc and Vitamin E Supplementation on Immune Response in Seropositive Leprosy Subjects. Pakistan Journal of Nutrition, 15: 40-44.

DOI: 10.3923/pjn.2016.40.44








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