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Pakistan Journal of Nutrition

Year: 2014 | Volume: 13 | Issue: 10 | Page No.: 584-588
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Authors

E.U. Madukwe

A.M. Okafor

C.M. Enemkpali

Keywords

Research Article

Effect of Blood Leaf (Iresine herbstii) Leaf Extract and Powder on the Biochemical Profile of Adult Male Albino Wistar Rats

E.U. Madukwe, A.M. Okafor and C.M. Enemkpali
This study assessed effect of Iresine herbstii leaf extract and powder on biochemical profile of adult male albino Wistar rats. Twenty adult male albino Wistar rats divided into four groups of five rats each were used for the study. All the animals received rat-chow and water ad-libitum. Group A was the control. Groups B, C and D received in addition, fresh leaf extract, shade-dried leaf extract and shade-dried leaf powder, respectively. Blood samples were obtained from the rats for lipid profile, liver and kidney function tests. Data obtained were analyzed using Statistical Package for Social Sciences (SPSS) for windows version 18. p<0.05 was accepted as level of significance. Serum AST was significantly (p<0.05) increased in rats fed fresh leaf extract. There was a significant (p<0.05) reduction in serum ALT of rats fed shade-dried leaf extract and powder. However, serum ALT of rats fed fresh leaf extract was significantly (p<0.05) increased. Serum ACP was significantly (p<0.05) increased in the three treatment groups. Serum creatinine was significantly (p<0.05) increased in rats fed fresh leaf extract. Rats fed shade-dried leaf powder showed a significant (p<0.05) increase in serum urea after treatment. Serum urea of rats fed fresh leaf extract was slightly reduced. There was a significant (p<0.05) increase in total cholesterol of rats fed fresh leaf extract whereas rats fed shade-dried leaf powder showed a significant (p<0.05) decrease in total cholesterol. Serum LDL-C of three treatment groups were increased. However, this was only significant (p<0.05) in rats fed shade-dried leaf extract.
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