• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Pakistan Journal of Nutrition
  2. Vol 8 (4), 2009
  3. 452-458
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Pakistan Journal of Nutrition

Year: 2009 | Volume: 8 | Issue: 4 | Page No.: 452-458
DOI: 10.3923/pjn.2009.452.458

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 613

Search


Authors


Shafaq Noori


Nayab Rehman


Madiha Qureshi


Tabassum Mahboob


Keywords


  • Carbon tetrachloride
  • liver injury
  • green tea
  • coffee
  • antioxidant enzymes
  • liver enzymes
Research Article

Reduction of Carbon Tetrachloride-Induced Rat Liver Injury by Coffee and Green Tea

Shafaq Noori, Nayab Rehman, Madiha Qureshi and Tabassum Mahboob
Cirrhosis is one of the most degenerative, world wide diseases and can be lead to an inability of liver functions. Green Tea (GT) and Coffee are natural products and considered as powerful antioxidant, chemoprotective, antiinflammatory and antitumorigenic agent. The present study was designed to investigate the protective effect of green tea and coffee against Carbon tetrachloride (CCl4)-induced liver cirrhosis by using biochemical and histopathological parameters. 24 Male Albino Wistar rats were randomly divided into 6 groups; each group consists of 4 rats. Group I comprises normal healthy rats remains untreated; Group II comprises of CCl4 (0.8 mg/kg) induced Cirrhotic rats; Group III was administered coffee orally (1 gm/100 mL) daily; Group IV administered CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 1% oral administration of coffee; Group V was administered 5% Green tea orally; Group VI comprises of CCl4 (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 5% oral administration of Green Tea. The volume of green tea and coffee ingested by rats of group III and V was measured daily. The effect of antioxidants on CCl4-induced liver cirrhosis were estimated by plasma ALT, ALP, total and direct bilirubin, tissue MDA, tissue SOD, tissue catalase. CCl4-induced cirrhosis is indicated by increased level of plasma ALT, direct bilirubin, tissue MDA and decreased level of tissue SOD. Pathological changes induced by CCl4 were characterized by fibrotic scar tissue as well as regenerative nodules, the parenchyma deteriorates; the lobules are infiltrated with fat and structurally altered; dense perilobular connective tissue. Coffee and green tea reduced these changes and also restored antioxidant and liver enzymes. Our results showed the possible protective effect of coffee and green tea in association with liver and antioxidant enzymes, indicated that administration of coffee and green tea not only reversed the pathological effects of CCl4 but also counteracted on deleterious effects of CCl4- induced liver injury.
PDF Fulltext XML References Citation

How to cite this article

Shafaq Noori, Nayab Rehman, Madiha Qureshi and Tabassum Mahboob, 2009. Reduction of Carbon Tetrachloride-Induced Rat Liver Injury by Coffee and Green Tea. Pakistan Journal of Nutrition, 8: 452-458.

DOI: 10.3923/pjn.2009.452.458

URL: https://scialert.net/abstract/?doi=pjn.2009.452.458

Related Articles

Hepatoprotective Effect of Senna mimosoides Aqueous Leaf Extract Against Carbon Tetrachloride Induced Hepatotoxicity in Albino Rats
Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats
A Check List on Ichthyofaunal Diversity of Bahuda Estuary, Odisha, East Coast of India
Low Doses of Gamma Radiation may Impair Testicular Tissue in a Rat Treated CCl4 Model: Role of BM Transplantation
Normalisation of Lipoprotein Phenotypes by Chromolaena odorata-Linn. in Carbon Tetrachloride Hepatotoxicity-Induced Dyslipidaemia

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved