Reduction of Carbon Tetrachloride-Induced Rat Liver Injury by Coffee and Green Tea


	Pakistan Journal of Nutrition
	Year: 2009 \| Volume: 8 \| Issue: 4 \| Page No.: 452-458 DOI: 10.3923/pjn.2009.452.458

Reduction of Carbon Tetrachloride-Induced Rat Liver Injury by Coffee and Green Tea

Shafaq Noori, Nayab Rehman, Madiha Qureshi and Tabassum Mahboob

Abstract: Cirrhosis is one of the most degenerative, world wide diseases and can be lead to an inability of liver functions. Green Tea (GT) and Coffee are natural products and considered as powerful antioxidant, chemoprotective, antiinflammatory and antitumorigenic agent. The present study was designed to investigate the protective effect of green tea and coffee against Carbon tetrachloride (CCl₄)-induced liver cirrhosis by using biochemical and histopathological parameters. 24 Male Albino Wistar rats were randomly divided into 6 groups; each group consists of 4 rats. Group I comprises normal healthy rats remains untreated; Group II comprises of CCl₄ (0.8 mg/kg) induced Cirrhotic rats; Group III was administered coffee orally (1 gm/100 mL) daily; Group IV administered CCl₄ (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 1% oral administration of coffee; Group V was administered 5% Green tea orally; Group VI comprises of CCl₄ (0.8 mg/kg) intraperitoneally once a week for 8 weeks+ 5% oral administration of Green Tea. The volume of green tea and coffee ingested by rats of group III and V was measured daily. The effect of antioxidants on CCl₄-induced liver cirrhosis were estimated by plasma ALT, ALP, total and direct bilirubin, tissue MDA, tissue SOD, tissue catalase. CCl₄-induced cirrhosis is indicated by increased level of plasma ALT, direct bilirubin, tissue MDA and decreased level of tissue SOD. Pathological changes induced by CCl₄ were characterized by fibrotic scar tissue as well as regenerative nodules, the parenchyma deteriorates; the lobules are infiltrated with fat and structurally altered; dense perilobular connective tissue. Coffee and green tea reduced these changes and also restored antioxidant and liver enzymes. Our results showed the possible protective effect of coffee and green tea in association with liver and antioxidant enzymes, indicated that administration of coffee and green tea not only reversed the pathological effects of CCl₄ but also counteracted on deleterious effects of CCl₄- induced liver injury.

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How to cite this article:

Shafaq Noori, Nayab Rehman, Madiha Qureshi and Tabassum Mahboob, 2009. Reduction of Carbon Tetrachloride-Induced Rat Liver Injury by Coffee and Green Tea. Pakistan Journal of Nutrition, 8: 452-458.

DOI: 10.3923/pjn.2009.452.458

URL: https://scialert.net/abstract/?doi=pjn.2009.452.458

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