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Pakistan Journal of Nutrition
  Year: 2009 | Volume: 8 | Issue: 8 | Page No.: 1164-1166
DOI: 10.3923/pjn.2009.1164.1166
 
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The Effects of Different Sizes of Nanometer Zinc Oxide on the Proliferation and Cell Integrity of Mice Duodenum-Epithelial Cells in Primary Culture
M. Feng, Z.S. Wang, A.G. Zhou and D.W. Ai

Abstract:
The MTT activity and LDH release were investigated in the proliferation and cell integrity of mice duodenum-epithelial cells which exposed to 10-15 nm and 100 nm nanometer zinc oxide (nano-ZnO). The mice duodenum-epithelial cells supplied two different sizes of nano-ZnO where supplemental Zn concentrations were 0, 0.4, 0.8, 1.6, 3.2, 6.4, 12.8 μg ml-1, respectively. The results showed that the MTT activity increased with the increased concentrations of 10-15 nm and 100 nm nano-ZnO, while the concentration 12.8 μg ml -1 of 10-15 nm nano-ZnO decreased the MTT activity. The LDH released increased significantly under the concentration 12.8 μg ml-1 of 100 nm nano-ZnO and 6.4 μg ml -1, 12.8 μg ml-1 of 10-15 nm nano-ZnO. In summary, the nano-ZnO promoted the proliferation of the cells and did not injury the cells at lower concentrations.
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How to cite this article:

M. Feng, Z.S. Wang, A.G. Zhou and D.W. Ai, 2009. The Effects of Different Sizes of Nanometer Zinc Oxide on the Proliferation and Cell Integrity of Mice Duodenum-Epithelial Cells in Primary Culture. Pakistan Journal of Nutrition, 8: 1164-1166.

DOI: 10.3923/pjn.2009.1164.1166

URL: https://scialert.net/abstract/?doi=pjn.2009.1164.1166

 
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