Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Nutrition
  Year: 2005 | Volume: 4 | Issue: 6 | Page No.: 371-375
DOI: 10.3923/pjn.2005.371.375
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
In-vitro and In-vivo Inhibition of Aspergillus fumigatus by Pseudomonas fluorescens Used as a Microbial Antagonist
O.O. Agarry and B.I. Osho

Abstract:
The potential inhibitory effect of Pseudomonas fluorescens from cassava starch and flour was studied by using: (I) in-vitro inhibition assays with Aspergillus fumigatus and (ii) the in-vivo A. fumigatus rats model of infection. In-vitro activity against A. fumigatus revealed a moderate capacity of the bacterium in inhibiting the growth of the fungus. In-vivo experiments were performed by oral administration of P. fluorescens to 12 -14 week-old rats previously infected with A. fumigatus. Toxicological data of rat plasma showed that the bacterium had liver improvement functions. Alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities of the rats dosed with P. fluorescens alone were lower (2.65 and 20.67 IU/L) than the control. Moreover, no significant (P>0.05) rise was observed with the plasma albumin, globulin and total protein. There was a reduction in the count of A. fumigatus in rats dosed with both organisms after 7 days of feeding trials. The weight gain by rats in the treated group compared favourably with the control. Histopathological data confirmed protection of the liver, spleen, and kidney while the stomach and small intestine had partial erosion of the mucus membranes.
PDF Citation Report Citation
 RELATED ARTICLES:
  •    Nutraceutical Effects of Fermented Whey on the Intestinal and Immune System of Healthy Albino Rats
How to cite this article:

O.O. Agarry and B.I. Osho , 2005. In-vitro and In-vivo Inhibition of Aspergillus fumigatus by Pseudomonas fluorescens Used as a Microbial Antagonist . Pakistan Journal of Nutrition, 4: 371-375.

DOI: 10.3923/pjn.2005.371.375

URL: https://scialert.net/abstract/?doi=pjn.2005.371.375

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

       

       

Curve Bottom