Sixty adult rats of both sexes were used for determination of LD50 of Anagallis arvensis. Other eighteen rats were used for repeated successive dose for determination of blood picture, kidney function and histopathological changes associated with A. arvensis toxicosis (1/5 and 1/10 LD50) IP for 15 days. The LD50 was 10.718 mg/kg.b.wt. of alcoholic extract of A. arvensis. The clinical signs included anorexia, restlessness, diarrhea, thirst, difficult breathing, tremors and ended by coma and death. Hematologically, there were a significant reduction in PCV%, Hb concentration and RBCs count of the intoxiced rats. Concerning kidney function tests, there were a significant increase in urea and creatinine level of the intoxicated rats. Pathologically, the lesions were primarily confined to the urinary system.