
	Pakistan Journal of Biological Sciences
	Year: 2021 \| Volume: 24 \| Issue: 1 \| Page No.: 80-89 DOI: 10.3923/pjbs.2021.80.89

Anti-inflammatory Effect of Red Macroalgae Bulung Sangu (Gracilaria sp.) Extract in UVB-Irradiated Mice

Maria Malida Vernandes Sasadara, I. Gede Putu Wirawan

, I. Made Jawi, Made Sritamin, Ni Nyoman Ayu Dewi

and Anak Agung Ayu Mirah Adi

Abstract: Background and Objective: Bulung Sangu, like many other macroalgae, is a source of beneficial phytochemical for health. This study was aimed to determine the anti-inflammatory effect of bulung sangu ethanol extract cream. Materials and Methods: The compounds of bulung sangu ethanol extract were identified by using gas chromatography. The antioxidant activity of the extract was examined by the DPPH assay. The anti-inflammatory effect was analyzed in vivo against ultraviolet B (UVB) induction through variables of epidermal thickening and epidermal erosion scores. Results: Our results showed that bulung sangu ethanol extract contained 18 compounds, in which, 11 compounds considered active as antioxidant and/or anti-inflammatory. Cream extract in both concentrations showed scavenging for more than 50%, with a concentration of 10% cream extract exhibited higher antioxidant activity compared to 5%. The in vivo assay showed a reduction of epidermal thickness and epidermal erosion in the application of both concentrations. The concentration of 10% cream extract showed higher reduction compared to 5% with results produced resembling normal. Conclusion: It can be concluded that bulung sangu displayed a potential source for being developed for the health and medicine aspect, especially for various activities supported by antioxidants and anti-inflammatory.

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How to cite this article:

Maria Malida Vernandes Sasadara, I. Gede Putu Wirawan, I. Made Jawi, Made Sritamin, Ni Nyoman Ayu Dewi and Anak Agung Ayu Mirah Adi, 2021. Anti-inflammatory Effect of Red Macroalgae Bulung Sangu (Gracilaria sp.) Extract in UVB-Irradiated Mice. Pakistan Journal of Biological Sciences, 24: 80-89.

DOI: 10.3923/pjbs.2021.80.89

URL: https://scialert.net/abstract/?doi=pjbs.2021.80.89

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