Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2018 | Volume: 21 | Issue: 9 | Page No.: 448-453
DOI: 10.3923/pjbs.2018.448.453
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Preparation and Characterization of Sustained Released Zinc Citrate Encapsulated in Whey Protein Nanoparticles
Tarek Nour Soliman and Mona Abd El Fattah Hassan

Abstract: Background and Objectives: The use of milk proteins for drug delivery is a new trend in functional foods and pharmaceutical. Recently, researchers have focused on the utilization of whey proteins in the preparation of nanoparticle and carrier for drugs and micronutrients. The objectives of this paper were to use whey proteins isolate (WPI) nanoparticles for the encapsulation of zinc citrate micronutrients and characterization of the prepared nanoparticles. Materials and Methods: Nanoparticles were prepared from WPI with pH cycling and used for the encapsulation and sustained release of zinc citrate with three ratios (7, 14 and 28 mM) of zinc citrate per gram WPI. The particle size of the prepared nanoparticles was characterization and examined by transmission electron microscopy. The release of Zinc from the prepared nanoparticles was carried out using simulated gastric fluid at pH 1.2 using dialysis membranes, the amount of zinc citrate loaded whey protein (14.36 mg Zinc in 1 g WPI) within range of daily dose of zinc for healthy adults. Results: The WPI nanoparticles were able to encapsulate efficiently zinc, with encapsulation efficiency that ranged between 99.79 and 96.31%. Zinc was highly released from the prepared nanoparticles in acidic media (pH 1.2). Conclusion: It can be concluded that WPI can be used as an effective vehicle for the protection and sustained release of zinc in food and pharmaceutical preparations.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Tarek Nour Soliman and Mona Abd El Fattah Hassan, 2018. Preparation and Characterization of Sustained Released Zinc Citrate Encapsulated in Whey Protein Nanoparticles. Pakistan Journal of Biological Sciences, 21: 448-453.

DOI: 10.3923/pjbs.2018.448.453

URL: https://scialert.net/abstract/?doi=pjbs.2018.448.453
COMMENT ON THIS PAPER
 
 
 

 
  Bullet Navigation
 
  Page Icon Online First
  Page Icon Current Issue
  Page Icon Previous Issues
  Page Icon Editorial Board
  Page Icon Submit a Manuscript
  Page Icon Guide to Authors
  Page Icon Subscribe to E-alerts

  Bullet Indexed In
 
  Page Icon AGRIS
  Page Icon ASCI-Database
  Page Icon Asian Digital Library
  Page Icon Cambridge Scientific Abstract
  Page Icon Chemical Abstract Services
  Page Icon Google Scholar
  Page Icon ISI Web of Knowledge
  Page Icon PubMed
  Page Icon SCIMAGO
  Page Icon Thomson ISI

Science Alert
Curve Bottom