• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Pakistan Journal of Biological Sciences
  2. Vol 21 (7), 2018
  3. 348-358
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Pakistan Journal of Biological Sciences

Year: 2018 | Volume: 21 | Issue: 7 | Page No.: 348-358
DOI: 10.3923/pjbs.2018.348.358

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 1004

Search


Authors


Sahar Y.  Al-Okbi

Sahar Y. Al-Okbi

LiveDNA: 20.16948

Ahmed M.S.  Hussein

Ahmed M.S. Hussein

LiveDNA: 20.16850

Hagar F.H. Elbakry

Country: Egypt

Karem Aly Fouda

Country: Egypt

Khaled F.  Mahmoud

Khaled F. Mahmoud

LiveDNA: 20.13002

Mohamed E. Hassan

Country: Egypt

Keywords


  • diuretic activity
  • rosemary
  • volatile oils
  • cardiovascular diseases
  • Fennel
  • dyslipidemia
Research Article

Health Benefits of Fennel, Rosemary Volatile Oils and their Nano-Forms in Dyslipidemic Rat Model

Sahar Y. Al-Okbi Sahar Y.  Al-Okbi's LiveDNA, Ahmed M.S. Hussein Ahmed M.S.  Hussein's LiveDNA, Hagar F.H. Elbakry, Karem Aly Fouda, Khaled F. Mahmoud Khaled F.  Mahmoud's LiveDNA and Mohamed E. Hassan
Background and Objective: Dyslipidemia is a major health problem that may lead to cardiovascular diseases (CVDs). In the present research, a biological experiment was run on dyslipidemic rats to study the health benefits of the volatile oils (VOs) of fennel and rosemary in its original and nano-form using chitosan as carrier. Materials and Methods: Rats were divided into 6 groups; normal control, dyslipidemic control and 4 test groups with dyslipidemia and treated by VOs of fennel and rosemary and their respective nano-forms separately. Glucose tolerance test was carried out after 4 weeks. Parameters reflecting oxidative stress/antioxidant plasma catalase, malondialdehyde (MDA) and blood uric acid, were assessed. Plasma lipid profile and tumor necrosis factor alpha (TNF-α) as inflammatory biomarker were determined. Liver and kidney function were assessed as determinant of the safety of the different VO forms. Twenty four hour urinary volume was measured to assess creatinine clearance and to evaluate the possible diuretic activity of the VOs. Results: Dyslipidemic control rats showed dyslipidemia, increased CVDs risk, liver dysfunction, elevated MDA and TNF-α with marked increase in blood sugar after half an hour of glucose ingestion compared to normal control. Treatment with the four VOs forms improved the majority of the biochemical parameters. Conclusion: All treatment showed cardio and hepato- protective effect and safety towards kidney and blood sugar. Oxidative stress and inflammatory biomarkers were significantly improved by the different treatments; both VO forms of fennel were more efficient in ameliorating inflammation.
PDF Fulltext XML References Citation

How to cite this article

Sahar Y. Al-Okbi, Ahmed M.S. Hussein, Hagar F.H. Elbakry, Karem Aly Fouda, Khaled F. Mahmoud and Mohamed E. Hassan, 2018. Health Benefits of Fennel, Rosemary Volatile Oils and their Nano-Forms in Dyslipidemic Rat Model. Pakistan Journal of Biological Sciences, 21: 348-358.

DOI: 10.3923/pjbs.2018.348.358

URL: https://scialert.net/abstract/?doi=pjbs.2018.348.358

Related Articles

Efficiency of Red Onion Peel Extract Capsules on Obesity and Blood Sugar
Roselle Seed as a Potential New Source of Healthy Edible Oil
Influence of Nano-encapsulation on Chemical Composition, Antioxidant Activity and Thermal Stability of Rosemary Essential Oil

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved