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Pakistan Journal of Biological Sciences
  Year: 2018 | Volume: 21 | Issue: 3 | Page No.: 135-150
DOI: 10.3923/pjbs.2018.135.150
Immunotherapy a New Hope for Cancer Treatment: A Review
Fatemeh Nouri Rouzbahani, Mohammad Shirkhoda, Feridon Memari, Hassan Dana , Ghanbar Mahmoodi Chalbatani , Habibollah Mahmoodzadeh, Nasim Samarghandi, Elahe Gharagozlou, Mohammad Hosein Mohammadi Hadloo, Ali Reza Maleki, Ehsan Sadeghian, ElhamZainali Nia, Nedazainali Nia, Farimah Hadjilooei, Omid Rezaeian, Saeed Meghdadi, SeyedRohollah Miri, Fatameh Jafari, Elham Rayzan and Vahid Marmari

Abstract:
Cancer is a major burden of disease worldwide with considerable impact on society. The tide of immunotherapy has finally changed after decades of disappointing results and has become a clinically validated treatment for many cancers. Immunotherapy takes many forms in cancer treatment, including the adoptive transfer of ex vivo activated T cells, oncolytic viruses, natural killer cells, cancer vaccines and administration of antibodies or recombinant proteins that either costimulate cells or block the so-called immune checkpoint pathways. Recently, cancer immunotherapy has received a high degree of attention, which mainly contains the treatments for programmed death ligand 1 (PD-L1), programmed death 1 (PD-1), chimeric antigen receptors (CARs) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). Here, this paper reviewed the current understandings of the main strategies in cancer immunotherapy (adoptive cellular immunotherapy, immune checkpoint blockade, oncolytic viruses and cancer vaccines) and discuss the progress in the synergistic design of immune-targeting combination therapies.
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How to cite this article:

Fatemeh Nouri Rouzbahani, Mohammad Shirkhoda, Feridon Memari, Hassan Dana, Ghanbar Mahmoodi Chalbatani, Habibollah Mahmoodzadeh, Nasim Samarghandi, Elahe Gharagozlou, Mohammad Hosein Mohammadi Hadloo, Ali Reza Maleki, Ehsan Sadeghian, ElhamZainali Nia, Nedazainali Nia, Farimah Hadjilooei, Omid Rezaeian, Saeed Meghdadi, SeyedRohollah Miri, Fatameh Jafari, Elham Rayzan and Vahid Marmari, 2018. Immunotherapy a New Hope for Cancer Treatment: A Review. Pakistan Journal of Biological Sciences, 21: 135-150.

DOI: 10.3923/pjbs.2018.135.150

URL: https://scialert.net/abstract/?doi=pjbs.2018.135.150

 
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