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Pakistan Journal of Biological Sciences
  Year: 2016 | Volume: 19 | Issue: 4 | Page No.: 185-190
DOI: 10.3923/pjbs.2016.185.190
 
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Measurement of Interleukin-6 in Cerebrospinal Fluid for the Diagnosis of Bacterial Meningitis
Ibrahim Dan Dano , Hassimi Sadou, Bassira Issaka and Odile Ouwe Missi Oukem-Boyer

Abstract:
Objective: It is assessed whether the measurement of interleukin-6 in the cerebrospinal fluid can serve as a biomarker for the diagnosis of bacterial meningitis. Methodology: Cerebrospinal fluid was obtained from 152 patients aged 0-15 years suspected of having meningitis. These patients were classified into the following groups: Bacterial meningitis (n = 85), aseptic meningitis (n = 35) and non-meningitis/control (n = 32) based on leukocyte count and bacterial identification by culture and molecular biology. Interleukin-6 concentrations in cerebrospinal fluid were measured by enzyme-linked immunosorbent assay. Results: This study found a significant difference of the mean cerebrospinal fluid interleukin-6 level (p≤0.01) between patients with bacterial meningitis (3,538.69±2,560.78 pg mL–1) and patients with aseptic meningitis (332.51±470.69 pg mL–1) or those of the control group (205.83±79.39 pg mL–1). There was also a significant difference of the mean cerebrospinal fluid interleukin-6 level between patients with aseptic meningitis and those of the control group. Interleukin-6 had the highest area under the ROC curve: 0.94 (95% confidence interval: 0.901-0.979) compared to that of cerebrospinal fluid glucose and total protein. At a cut-off value of 1,065.96 pg mL–1, interleukin-6 had a sensitivity of 76.2% and specificity of 100%. Conclusion: Interleukin-6 is a potential biomarker for the differential diagnosis of meningitis.
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How to cite this article:

Ibrahim Dan Dano, Hassimi Sadou, Bassira Issaka and Odile Ouwe Missi Oukem-Boyer, 2016. Measurement of Interleukin-6 in Cerebrospinal Fluid for the Diagnosis of Bacterial Meningitis. Pakistan Journal of Biological Sciences, 19: 185-190.

DOI: 10.3923/pjbs.2016.185.190

URL: https://scialert.net/abstract/?doi=pjbs.2016.185.190

 
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