Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2014 | Volume: 17 | Issue: 6 | Page No.: 855-859
DOI: 10.3923/pjbs.2014.855.859
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Psychopharmacological Potentials of Methanol Leaf Extract of Securinega virosa Roxb (Ex Willd) Baill. in Mice

M.G. Magaji, Y. Yakubu, R.A. Magaji, A.M. Musa, A.H. Yaro and I.M. Hussaini

Abstract:
Schizophrenia is a highly disabling chronic psychiatric illness. The existing antipsychotic agents are associated with untoward effects and drug interactions leading to the intensification of search for newer agents with better efficacy and safety profile. Securinega virosa is a commonly used medicinal plant in African traditional medicine. The decoction of the leaves of the plant in combination with other plants is used in the management of mental illness. In this study, we evaluate the antipsychotic potential of the methanol leaf extract (25, 50 and 100 mg kg-1) of the plant using apomorphine-induced stereotypic climbing behavior and swim-induced grooming tests, all in mice. The CNS depressant effect was also evaluated using ketamine-induced sleep test mice. The extract at the highest dose tested (100 mg kg-1) significantly reduced the apomorphine (1 mg kg-1)-induced stereotypic climbing behavior after 30 min. Similarly, haloperidol (2 mg kg-1), the standard agent significantly (p<0.001) decreased the mean climbing behavior. In the swim-induced grooming test, the extract significantly (p<0.01) and dose-dependently decreased the total grooming time. Similarly, haloperidol (2 mg kg-1) significantly (p<0.001) decreased the mean grooming activity. The extract significantly increased the total ketamine-induced sleep duration at doses of 50 and 100 mg kg-1. These findings suggest that the extract possesses antipsychotic and sedative potentials and lend credence to the ethnomedical use of the leaves of the plant in the management of mental illness.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

M.G. Magaji, Y. Yakubu, R.A. Magaji, A.M. Musa, A.H. Yaro and I.M. Hussaini, 2014. Psychopharmacological Potentials of Methanol Leaf Extract of Securinega virosa Roxb (Ex Willd) Baill. in Mice. Pakistan Journal of Biological Sciences, 17: 855-859.

DOI: 10.3923/pjbs.2014.855.859

URL: https://scialert.net/abstract/?doi=pjbs.2014.855.859

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

Curve Bottom