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A Decade of Follow-up and Therapeutic Drug Monitoring in HIV-2 Immunocompromised Patients at St Camille and General Lamizana Military Medical Centers, Burkina Faso, West Africa |
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M. Sanou,
S.T. Soubeiga,
F. Bationo,
T.R. Compaore,
T.M. Zohoncon,
G.N. Diatto,
P. Ouedraogo,
V. Pietra,
B.M. Nagalo,
C. Bisseye,
R. Ouedraogo Traore and J. Simpore |
Abstract:
Although, HIV-2 is generally less pathogenic than HIV-1 and
its progression towards AIDS occurs less frequently. HIV-2 remains an important
cause of disease in West Africa. This study aimed to evaluate HIV-1 and HIV-2
prevalence among pregnant women and to describe the demographic and clinical
profile of patients with HIV-2 infection from 2003-2013 at St Camille and General
Lamizana Military Medical Centers. A retrospective investigation was conducted
using 12,287 medical records from patients screened for HIV. To respond to the
lack of data available regarding HIV-2 treatment and also to address the approach
to clinical, biological as well as therapeutic monitoring, 62 HIV-2 infected
patients’ medical records were
studied. Seroprevalence of 10.6 and 0.14% were obtained, respectively for HIV-1
and HIV-2 among 12,287 women screened during the study period. From the sixty
two (62) HIV-2 patients, the average age was 49.2 years (sex ratio was 0.65).
The weight loss and diarrhea were the major clinical manifestations observed,
respectively 54.8 and 25.8%. Fungi and herpes zoster (shingles) infections were
reported as major opportunistic infections. Also, nearly half of the patients
had more than 60 kg, less than 2% were in WHO stage IV and about 2/3 had a CD4
count bellow 250 cells mm-3. AZT-3TC-IDV/LPV/R was the most prescribed
combination. The gain in weight gain the Body Mass Index (BMI) improvement and
the non-significant increase of the rate of CD4 between 1st (M1) and 24th month
(M24) were observed after treatment with antiviral.
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How to cite this article:
M. Sanou, S.T. Soubeiga, F. Bationo, T.R. Compaore, T.M. Zohoncon, G.N. Diatto, P. Ouedraogo, V. Pietra, B.M. Nagalo, C. Bisseye, R. Ouedraogo Traore and J. Simpore, 2014. A Decade of Follow-up and Therapeutic Drug Monitoring in HIV-2 Immunocompromised Patients at St Camille and General Lamizana Military Medical Centers, Burkina Faso, West Africa. Pakistan Journal of Biological Sciences, 17: 1219-1224.
DOI: 10.3923/pjbs.2014.1219.1224
URL: https://scialert.net/abstract/?doi=pjbs.2014.1219.1224
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