Potent α-Glucosidase Inhibitors Isolated from Ginkgo biloba Leaves

Research Article

**Potent α-Glucosidase Inhibitors Isolated from Ginkgo biloba Leaves**

In vitro α-glucosidase inhibitory activity of Ginkgo biloba leaves was investigated. The inhibitory activity of methanol extracts from yellow and green leaves was 13.8 and 40.1 μg mL^-1, respectively. Each methanol extract was separated into its respective fraction by solvent-solvent extraction with n-hexane, chloroform, ethyl acetate and n-butanol. The n-hexane fractions (in both methanol extracts from green and yellow leaves) exhibited high α-glucosidase inhibitory activity with IC₅₀ values of 13.6 and 13.4 μg mL^-1, respectively. Further fractionation of the n-hexane fractions by silica gel column chromatography gave the most active fraction which was identified as ginkgolic acid (C13:0) and a mixture (C13:0, C15:0, C15:1, C17:1 and C17:2). Ginkgolic acid (C13:0) exhibited the highest α-glucosidase inhibitory activity. This is the first study to successfully isolate ginkgolic acids as α-glucosidase inhibitors.

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Agus Sukito and Sanro Tachibana, 2014. Potent α-Glucosidase Inhibitors Isolated from Ginkgo biloba Leaves. Pakistan Journal of Biological Sciences, 17: 1170-1178.

DOI: 10.3923/pjbs.2014.1170.1178

URL: https://scialert.net/abstract/?doi=pjbs.2014.1170.1178

Pakistan Journal of Biological Sciences

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Agus Sukito

Sanro Tachibana

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Research Article

**Potent α-Glucosidase Inhibitors Isolated from Ginkgo biloba Leaves**

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