Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2013 | Volume: 16 | Issue: 14 | Page No.: 697-700
DOI: 10.3923/pjbs.2013.697.700
Evaluation of Acute Toxicity of Water Extract of Azadirachta indica Leaves and Seeds in Rats
Shori Amal Bakr

Abstract:
This study ‘in vivo’ was applied on rats “Rattus norvegicus” to determine the acute toxicity of water extracts of Azadirachta indica leaves and seeds during 48 hours and the 50% lethal dose (LD50) values were calculated. Different doses of A. indica water extracts of leaves and seeds were injected to the rats (Rattus norvegicus) and the percentage of death was recorded during 48 hours. The present study, found that the percentage of death in all treated rats with A. indica leaves and seeds water extracts were increased by doses increased (R2 = 0.9). Rats injected with higher doses of water extract of A. indica leaves (0.1 and 0.092 g mL-1) and seeds (0.2 g mL-1) showed 100% death. The LD50 of water extract of A. indica leaves and seeds were 6.2, 9.4 mL kg-1, respectively. Based on these results, it may be concluded that doses of water extract of A. indica leaves and seeds injected to rats showed significant acute toxicity.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Shori Amal Bakr , 2013. Evaluation of Acute Toxicity of Water Extract of Azadirachta indica Leaves and Seeds in Rats. Pakistan Journal of Biological Sciences, 16: 697-700.

DOI: 10.3923/pjbs.2013.697.700

URL: https://scialert.net/abstract/?doi=pjbs.2013.697.700

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom