Advances in the Research of AMPK and its Subunit Genes


	Pakistan Journal of Biological Sciences
	Year: 2013 \| Volume: 16 \| Issue: 22 \| Page No.: 1459-1468 DOI: 10.3923/pjbs.2013.1459.1468

Advances in the Research of AMPK and its Subunit Genes

W.Y. Liu and R.S. Jiang

Abstract: AMP-activated kinase (AMPK) is a heterotrimeric complex composed of three subunits and is the core energy sensor of the cell. The AMPK activity is important for survival during periods of stress and starvation and also has implications in type II diabetes, obesity, metabolic syndrome, longevity and cancer, etc. The activation of AMPK is triggered through binding of Adenosine Monophosphate Activated Proteins (AMP) to the Bateman domains of the gamma subunit, leading to increased phosphorylation of the threonine 172 on the alpha subunit by inducing allosteric activation and inhibiting dephosphorylation. AMPK and its subunits have been the focuses of many researchers dealing with genetic and metabolic issues. The study makes a comprehensive review on the structure, function, distribution, enzyme activity, the genetic mutation and other aspects of AMPK and its subunit genes, with the aim to outline main aspects of present researches on AMPK and its subunits in animal genetics.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Response of Broiler Chickens Fed on Maize-based Diets Substituted with Graded Levels of Sweet Potato Meal

•	Effect of Slaughtering Age on Chemical Composition of Goat Meat

•	Examination of Physical Properties of Goat Meat

•	The Polymorphisms of Goat THRSP Gene Associated with Ecological Factors in Chinese Indigenous Goat Breeds with Different Lipogenesis Ability

How to cite this article:

W.Y. Liu and R.S. Jiang, 2013. Advances in the Research of AMPK and its Subunit Genes. Pakistan Journal of Biological Sciences, 16: 1459-1468.

DOI: 10.3923/pjbs.2013.1459.1468

URL: https://scialert.net/abstract/?doi=pjbs.2013.1459.1468

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		Chemical Abstract Services
		Google Scholar
		ISI Web of Knowledge
		PubMed
		SCIMAGO
		Thomson ISI

Follow @scialert

Science Alert