The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial


	Pakistan Journal of Biological Sciences
	Year: 2012 \| Volume: 15 \| Issue: 2 \| Page No.: 98-102 DOI: 10.3923/pjbs.2012.98.102

The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial

N. Namazi, A. Tarighat and A. Bahrami

Abstract: Diabetes type 2 is a metabolic disorder that characterized by hyperglycemia and insulin resistance. Hyperglycemia and impairment of oxidant/antioxidant balance, can increase oxidative stress and increase risk of cardiovascular disease. In the present study, Effects of hydro alcoholic extract of Nettle on oxidative stress in type 2 diabetes were evaluated. Fifty patients (27 men, 23 women) with type 2 diabetes patients were studied. They received 100 mg kg^-1 of nettle extract of body weight hydro alcoholic for 8 weeks. At the baseline and end of 8th weeks of intervention blood levels of oxidative stress markers were measured. Data was analyzed by SPSS version 18, p<0.05 was considered significant for all variables. After 8 weeks, Total Antioxidant Capacity (TAC) and Superoxidant Dismutase (SOD) showed a significant increase in the intervention group compared to the control group (p<0.05). The findings showed that the hydro alcoholic extract of nettle has increasing effects on TAC and SOD in patients with type 2 diabetes without no changes in Malondialdehyde (MDA) and Glutathione Peroxides (GPX) after eight weeks intervention.

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How to cite this article:

N. Namazi, A. Tarighat and A. Bahrami, 2012. The Effect of Hydro Alcoholic Nettle (Urtica dioica) Extract on Oxidative Stress in Patients with Type 2 Diabetes: A Randomized Double-blind Clinical Trial. Pakistan Journal of Biological Sciences, 15: 98-102.

DOI: 10.3923/pjbs.2012.98.102

URL: https://scialert.net/abstract/?doi=pjbs.2012.98.102

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