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Pakistan Journal of Biological Sciences
  Year: 2012 | Volume: 15 | Issue: 16 | Page No.: 789-794
DOI: 10.3923/pjbs.2012.789.794
Interventional Therapy in Diabetic Foot: Risk Factors, Clinical Events and Prognosis at One Year Follow-up (A Study of 103 Cases)
Marco Matteo Ciccone, Alfredo Marchese, Aikaterini Generali, Cataldo Loiodice, Francesca Cortese, Rosa Carbonara, Pietro Scicchitano, Luigi Laviola and Francesco Giorgino

Abstract:
Diabetic foot is a common complication in diabetes mellitus course, able to increase the overall morbidity/mortality risk of such a disease. The aim was to investigate the outcomes, the incidence of clinical events, the number of recurrent ulcers in patients with diabetic foot during 1 year follow-up after angioplasty (PTA) revascularization. From January 2007 to August 2009, 103 diabetic patients with diabetic foot undergoing revascularization of a lower limb by PTA were recruited. At 1 year follow-up we assessed: “major” (death, stroke, Myocardial Infaction (MI) and “minor” (Deep Vein Thrombosis (DVT), renal failure, restenosis) events incidence; recurrent ulcers incidence; the predictive elements of all these events. At 1 year follow-up, “major”/“minor” events incidence was 15% (deaths:5, stroke:1, MI: 9%) and 34% (renal failure: 11, DVT: 9, restenosis: 14%), respectively. Obesity, high low density level-cholesterol levels and distal arterial lesions (at posterior tibial artery in particular) were statistically significantly associated with major events (p<0.05); only obesity resulted statistically associated with minors (p = 0.043). High levels of C-reactive protein had a statistically significant relationship with the recurrence of ulcers (p = 0.006) while distal arterial obstructions showed a trend toward significance. To improve diabetic foot mortality and morbidity rate, our study underlines the importance of a prompt diagnosis and appropriate revascularization treatment. Other studies are needed to ascertain these.
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How to cite this article:

Marco Matteo Ciccone, Alfredo Marchese, Aikaterini Generali, Cataldo Loiodice, Francesca Cortese, Rosa Carbonara, Pietro Scicchitano, Luigi Laviola and Francesco Giorgino, 2012. Interventional Therapy in Diabetic Foot: Risk Factors, Clinical Events and Prognosis at One Year Follow-up (A Study of 103 Cases). Pakistan Journal of Biological Sciences, 15: 789-794.

DOI: 10.3923/pjbs.2012.789.794

URL: https://scialert.net/abstract/?doi=pjbs.2012.789.794

 
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