Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2012 | Volume: 15 | Issue: 6 | Page No.: 290-295
DOI: 10.3923/pjbs.2012.290.295
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Preparation and Evaluation of Gastroretentive Floating Pellets of Metronidazole Using Na-alginate and Hydroxyl Propyl Methyl Cellulose Polymers
S.K. Biswas, S. Paul, A. Chowdhury and J. Das

Abstract:
Gastroretentive floating pellets of metronidazole were formulated to prolong the gastric residence time in order to obtain controlled release characteristics of the drug. Nine formulations of metronidazole floating pellets such as AX, BX, CX, AY, BY, CY, AZ, BZ and CZ were prepared by extrusion method using different quantities of hydroxyl propyl methyl cellulose (HPMC) polymers such as methocel K4M premium and methocel K100LV premium in the ratio of 2:1, 1:2 and 1.5:1.5 while the amount of Na-alginate used in the formulations was 3.50, 5.25 and 7.0 g, respectively. The in vitro dissolution studies were carried out in 900 mL of phosphate buffer (pH 1.2) at 37±0.5°C and 50 rpm for 6 h using USP XXIV paddle method and the content of drug release was done by UV spectrophotometer at 277 nm. It was found that the percent release of metronidazole from different formulations was different with passing of time. The drug release profile of the formulation (AX) having Na-alginate 3.50 g methocel K4M premium and methocel K100LV premium in the ratio of 2:1 showed best fit to Higuchi release kinetics with R2 value of 0.994. Finally, it might be concluded that the polymers had significant effect on drug release kinetics of metronidazole from floating pellets. The selection and use of suitable polymers in appropriate ratio might be very important in designing floating pellets and using the capabilities of these polymers, suitable floating pellets of metronidazole with desirable release rate could be formulated. Thus, in vivo research studies by the future researchers will confirm the appropriateness of these formulated metronidazole floating pellets.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    pH Sensitive Drug Delivery Systems: A Review
  •    Effect of Waxy Materials on the Release Kinetics of Ibuprofen from HPMC Based Sustained Release Matrix Tablet
  •    Controlled Release Oral Dosage Forms: Some Recent Advances in Matrix Type Drug Delivery Systems
  •    Formulation and Evaluation of Simvastatin Injectable in situ Implants
How to cite this article:

S.K. Biswas, S. Paul, A. Chowdhury and J. Das, 2012. Preparation and Evaluation of Gastroretentive Floating Pellets of Metronidazole Using Na-alginate and Hydroxyl Propyl Methyl Cellulose Polymers. Pakistan Journal of Biological Sciences, 15: 290-295.

DOI: 10.3923/pjbs.2012.290.295

URL: https://scialert.net/abstract/?doi=pjbs.2012.290.295

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom