Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 11 | Page No.: 641-646
DOI: 10.3923/pjbs.2011.641.646
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Human Papillomavirus Infection in Lung vs. Oral Squamous Cell Carcinomas: A Polymerase Chain Reaction Study
Monireh Halimi, Sam Morshedi Asl, Mohammad Saeid Hejazi, Amirala Aghbali and Mohammad Esmaeil Hejazi

Abstract:
The role of Human Papillomavirus (HPV) has been suspected in pathogenesis of various malignancies; however, the available data are not conclusive. This study aimed to determine and compare the frequency of HPV infection in oral and lung Squamous Cell Carcinoma (SCC) by a sensitive method. Sixty specimens of oral and lung SCC (30 cases each one) were reevaluated in Tabriz Imam Reza Centre in a 24 month period. Following genomic DNA extract, the Polymerase Chain Reaction (PCR) amplification was performed in presence of specific MY11 and MY09 primers for HPV infection. Three cervical specimens and a combination of PCR solution lacking DNA plus healthy persons' DNA samples were employed as positive and negative controls, respectively. The oral group was significantly older than the lung group (68.90 vs. 56.67 y, p<0.001) with more males in the latter (83.3 vs. 60%; p = 0.04). Percentages of HPV infection in the oral and lung groups were comparable (20 vs. 10%, respectively; p = 0.47). Majority of patients with HPV infection were older than 60 years (88.9%) or male (88.9%). In the oral group, all these cases were well differentiated and the majority was of lower lip origin (83.3%). In the lung group, 66.7% of these specimens were moderately differentiated and the origin was bronchus in all cases. In conclusion, the rate of HPV infection in lung and oral SCC samples is rather lower than the previous reports in the literature. This rate is apparently higher in the oral than the lung SCC specimens.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Public Perceptions of Cancer Risk using Analytic Hierarchy Process
  •    Human Papillomavirus In Spontaneous Abortion
  •    The Role of Viruses in Oral Squamous Cell Carcinoma in Young Patients in Khorasan (Northeast of Iran)
  •    Oral Cancer and Gene Polymorphisms: International Status with Special Reference to India
How to cite this article:

Monireh Halimi, Sam Morshedi Asl, Mohammad Saeid Hejazi, Amirala Aghbali and Mohammad Esmaeil Hejazi, 2011. Human Papillomavirus Infection in Lung vs. Oral Squamous Cell Carcinomas: A Polymerase Chain Reaction Study. Pakistan Journal of Biological Sciences, 14: 641-646.

DOI: 10.3923/pjbs.2011.641.646

URL: https://scialert.net/abstract/?doi=pjbs.2011.641.646

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom