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Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 6 | Page No.: 363-374
DOI: 10.3923/pjbs.2011.363.374
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Immune Modulation in Response to Stress and Relaxation

Mahbub-E-Sobhani , N. Haque, U. Salma and A. Ahmed

Traditional medical science has kept the mind separate from the body. Recently people realize the effect of mind on health and psychoneuroimmunology is the new evolved science that describes the interactions between psyche and soma. In this review through a typical psycho-neuro-endocrino-immune network the effects of psychological stress (acute, brief naturalistic and chronic) and relaxation on immune modulation has been shown. From this network Corticotrophin Releasing Factor (CRF), Adrenocorticotrophic Hormone (ACTH), Glucocorticoids (GC), α-endorphin and Met-enkephalin are found as important endocrine components and T cells, B cells, monocytes/macrophages, Natural Killer (NK) cells and their cytokines that is Tumor Necrosis Factor-α (TNF-α), Interferon Gamma (IFN-α) and interleukins such as IL-1, IL-2, IL-4, IL-6, IL-10, IL-12 etc. are found as important immune components. Finally, it has been shown that, acute, brief naturalistic and chronic stress have different immune modulatory activities which are harmful to one’s homeostasis and relaxation can help to maintain that homeostasis.
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  •    The Impact of Stress on Cardiovascular Disease in Pre- and Post-Menopausal Women
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  •    Catecholamine and Corticosteroid Secretion and Gene Expression of the Synthesizing Enzymes in Adrenal Glands of SHRSP and WKY in Response to Cold Stress
  •    Effects of Practical Examination Stress on Serum ACTH and Cortisol Concentrations in Normal and Anxious Students
  •    Brief Naturalistic Stressors Cause Shift of TH1 to TH2 Cytokine Response and Increase Disease Susceptibility
How to cite this article:

Mahbub-E-Sobhani , N. Haque, U. Salma and A. Ahmed, 2011. Immune Modulation in Response to Stress and Relaxation. Pakistan Journal of Biological Sciences, 14: 363-374.

DOI: 10.3923/pjbs.2011.363.374






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