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Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 5 | Page No.: 313-326
DOI: 10.3923/pjbs.2011.313.326
Abnormal Serum Thyroid Hormones Concentration with Healthy Functional Gland: A Review on the Metabolic Role of Thyroid Hormones Transporter Proteins
Azad Reza Mansourian

Laboratory findings can definitely help the patients not to enter into status, where the damage might be happen due to a miss-diagnosis based on clinical assessment alone. The secondary disease accompanied with thyroid patients should also carefully check out due to the interference which some diseases can cause in the amount of serum thyroid hormone, particularly the free thyroxin. The dilemma over thyroid clinical diagnosis occur due to variation on serum thyroid hormone which initiated by other non-thyroidal disorders which can play an important roles in metabolic disorders of thyroid hormone due to the alteration which occur on the serum level of thyroid hormone transporter proteins. The majority of serum thyroid hormones of up to 95-99% are bound to the carrier proteins mainly to Thyroxin-Binding Globulins (TBG), some transthyretin already known as pre-albumin and albumin which are all synthesis in the liver and any modification which alter their production may alter the status of thyroid hormones. It seems TBG, transthyretin and albumin carries 75, 20, 5% of thyroid hormones within blood circulation, respectively. The dilemma facing the thyroid hormones following disruption of thyroid hormone transporter protein synthesis originate from this fact that any alteration of these protein contribute to the alteration of total thyroid and free serum thyroid hormones which are in fact the biologically active form of thyroid hormones. The subsequent of latter implication result in miss-understanding and miss-diagnosis of thyroid function tests, with possible wrongly thyroid clinical care, followed by undesired therapy of otherwise healthy thyroid.
PDF Fulltext XML References Citation Report Citation
  •    A Review of Literature on Thyroid Hormone Disorders Originated from Extra Thyroidal Illness
  •    Liver Functional Behavior During Thyrotoxicosis: A Review
  •    Clinical Diagnostic Laboratory Play a Crucial Role in the Management of Thyroid Disorders: A Literature Review
  •    A Review of Literatures on the Adverse Effects of Thyroid Abnormalities and Liver Disorders: An Overview on Liver Dysfunction and Hypothyroidism
  •    The Effect of Ambient Temperature on Thyroid Hormones Concentration and Histopathological Changes of Thyroid Gland in Cattle in Tabriz, Iran
  •    Physiological Factors Associated with Weak Neonatal Poults (Meleagris gallopavo)
  •    Maternal Dietary Iodide Influences Turkey Embryo Thyroid Function
  •    A Survey of Urinary Iodine Concentration in South-east of Caspian Sea in Northern, Iran
How to cite this article:

Azad Reza Mansourian , 2011. Abnormal Serum Thyroid Hormones Concentration with Healthy Functional Gland: A Review on the Metabolic Role of Thyroid Hormones Transporter Proteins. Pakistan Journal of Biological Sciences, 14: 313-326.

DOI: 10.3923/pjbs.2011.313.326


08 May, 2011
Gur Nihal:
It is an excuist attempt.Congrats to Authors for valiant expressions.






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