Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Pakistan Journal of Biological Sciences
  Year: 2011 | Volume: 14 | Issue: 3 | Page No.: 219-225
DOI: 10.3923/pjbs.2011.219.225
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail
Effects of Taurine on Glutathione Peroxidase, Glutathione Reductase and Reduced Glutathione Levels in Rats
P. Anand, D. Rajakumar, Mathew Jeraud, A. John William Felix and T. Balasubramanian

Abstract:
The aim of the present study is to investigate the effects of oral administration of taurine on endogenous glutathione peroxidase (GPx) and Glutathione Reductase (GR) activities and reduced glutathione (GSH) level in normal rats. Normal saline (Group I) or 5% taurine in normal saline was administered in dose of 50 mg (Group II), 250 mg (Group III) or 500 mg kg-1 of body weight (Group IV) through intragastric intubation for 60 days. GPx and GR enzyme activities and GSH and taurine levels were determined in liver, heart, stomach, kidney and plasma of normal Wistar rats. GPx activity showed an increase in liver, heart, stomach and plasma. GR activity increased in kidney and decreased in liver and plasma. GSH levels increased in liver, stomach and decreased in kidney. Liver showed an increase and heart, stomach and kidney a decrease in taurine level in taurine administered rats when compared to control rats. The results varied from organ to organ and the observed variations among organs might be related to their respective enzymatic, non-enzymatic antioxidant potential and its functions. From the present study it may be concluded that long term oral administration of taurine affects GPx, GR and GSH levels in normal rats.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Effects on Renal Histology, Renal Metabolizing Enzymes and Oxidative Stress Biomarkers in Rats Administered Zerumbone Against Osteoarthritis
  •    Some Activities of Peroxidase from Mango (Mangifera indica L. Var. Mapulehu) Kernel
  •    Prevention of Alloxan Induced Diabetes Mellitus in Rats by Vitamin a Dietary Supplementation
  •    The Effects of Taurine on Aminolevulinic Acid Dehydratase Activity in Nonylphenol-Induced Toxicity
  •    Sexual Dimorphism in the Effect of a Taurine Supplemented Diet on Life Span in Adult Drosophila melanogaster
  •    Renal Damage Mediated by Oxidative Stress in Mice Treated with Aluminium Chloride: Protective Effects of Taurine
How to cite this article:

P. Anand, D. Rajakumar, Mathew Jeraud, A. John William Felix and T. Balasubramanian, 2011. Effects of Taurine on Glutathione Peroxidase, Glutathione Reductase and Reduced Glutathione Levels in Rats. Pakistan Journal of Biological Sciences, 14: 219-225.

DOI: 10.3923/pjbs.2011.219.225

URL: https://scialert.net/abstract/?doi=pjbs.2011.219.225

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom